About the book
Rheumatoid arthritis (RA) is a chronic synovial joints inflammation and pain related to an autoimmune disease. As there is no effective cure, RA is distressing notably by affecting disability and psychosocial outcomes. In fact, pain is not only due to joint inflammation but also increased by central sensitization and structural joint damage. In the absence of appropriate treatment this can lead to joint destruction and disability. Thus, early diagnosis and initiation of treatment are important. Prognosis of RA requires a full assessment of pain mechanisms by clinical history and examination. It may be also predicted based on the presence of some clinical and laboratory evidences. Significant progress has been made over the past years regarding understanding of disease pathophysiology and new therapies have been developed in response to new pathogenetic findings. Herein, early diagnosis and treatment outcomes approaches are described. These include latest diagnosis options, molecular mechanism pathogenesis and management options.