Open access peer-reviewed Edited Volume

Cellular Prion Protein - at the Crossroads of Prion Diseases and Other Amyloid Neurodegenerative Diseases

Yannick Bailly

University of Strasbourg


Benoit Schneider

Paris Descartes University


Synapse Stress Myelin Maintenance PrPc Loss of Function Apoptosis Chronic Wasting Disease CWD Prion Transmission Scrapie Cross-Species Barrier Alzheimer's Disease Prionoid

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About the book

Despite intensive research, prion diseases still remain fatal neurodegenerative disorders. Since the discovery of the host-encoded cellular prion protein PrPC over 30 years ago, much advance has been made to define PrPC as a critical mediator of prion-induced neuronal death and to delineate some mechanisms of neurodegeneration occurring in prion diseases and in other amyloid diseases like Alzheimer’s. PrPC has been identified as a receptor for Aβ oligomeric species (Aβo) that also relays Aβo toxicity. The Aβo/PrPC interaction notably provokes synaptic damage in Alzheimer’s brain, supporting the view of an Aβo pathocascade that connects Aβ and tau pathologies. In line with this, soluble tau seeds would transmit amyloid-β pathology and potentially Alzheimer’s disease and behave as prionoids that propagate and spread from cell to cell.
The emergence of novel prion strains in animals, which include the only evidenced zoonotic prion C-BSE causing vCJD in humans, has created an important public health concern. Currently, new threats to human and animals may develop because of the plausible zoonotic properties of scrapie, L-BSE and the recently emerging chronic wasting disease in Europe.
This book will gather experts in prion diseases and present new scientific advances in the field and relations with other amyloid neuropathologies.

Publishing process

Book initiated and editor appointed

Date completed: September 10th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: November 30th 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: February 18th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: April 18th 2020

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About the editor

Yannick Bailly

University of Strasbourg

Yannick Bailly was born in 1956. During his Ph.D. at the University of Strasbourg and the University of P. & M. Curie in Paris, he deciphered the nervous system controlling fish gill exchanges. Afterward, at the CNRS in Paris, he greatly improved the understanding of synapse elimination in the developing rodent cerebellum. Since 1994, after returning to Strasbourg as a CNRS Research Director, his laboratory has become renowned for its expertise in ultrastructural neuroanatomy. Yannick Bailly has made major contributions concerning the synaptic localization of cardinal molecules involved in neurodegenerative diseases, such as amyloid precursor proteins and presenilins in Alzheimer’s disease and prion protein. His research group has provided valuable insight into neuronal death mechanisms involved in brain pathologies, in particular in prion diseases.

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Book chapters authored 1

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