About the book
The book "Chromatin Organization in Health and Disease" aims to provide the reader with a concise and coherent account of the nature, structure, and assembly of chromatin and role of chromatin remodeling in gene regulation during development, differentiation and in disease. DNA damage affects both the stability of the genome and its structure of histone proteins in chromatin ( major shifts in the nature of the histone variants and alterations of the histone). While these alterations endanger epigenome stability, they are also instrumental in achieving an effective and timely response to DNA damage. Changes in histone protein help alleviate the chromatin barrier to DNA repair by controlling compaction and movement of chromatins.
This book aims to clarifiy the remarkable role of 3D chromatin architecture in development and delineates its alterations as prominent causes of disease. This book hopes to clearly interrelate the chromatin structure with the biochemical pathways it influences, and would be important reading for students and molecular biologists who also want to grasp epigenetic and transcriptional disease mechanisms.