Open access peer-reviewed Edited Volume

Chromatin Organization in Health and Disease

Jehane Eid

Cairo University

A pioneering researcher in molecular biology and an Associate Professor from Cairo University interested in the genotoxic/anti-genotoxic effects of natural compounds.


Chromatin Structure Nucleosome Chromatin Remodeling Chromatin-Associated RNA DNA Damage Nuclear Organization Nucleosome Remodelers Histones Oxidative Stress Epigenetics Gene Regulation Genetic Disease

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About the book

The book "Chromatin Organization in Health and Disease" aims to provide the reader with a concise and coherent account of the nature, structure, and assembly of chromatin and role of chromatin remodeling in gene regulation during development, differentiation and in disease. DNA damage affects both the stability of the genome and its structure of histone proteins in chromatin ( major shifts in the nature of the histone variants and alterations of the histone). While these alterations endanger epigenome stability, they are also instrumental in achieving an effective and timely response to DNA damage. Changes in histone protein help alleviate the chromatin barrier to DNA repair by controlling compaction and movement of chromatins.

This book aims to clarifiy the remarkable role of 3D chromatin architecture in development and delineates its alterations as prominent causes of disease. This book hopes to clearly interrelate the chromatin structure with the biochemical pathways it influences, and would be important reading for students and molecular biologists who also want to grasp epigenetic and transcriptional disease mechanisms.

Publishing process

Book initiated and editor appointed

Date completed: October 27th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: January 23rd 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: April 13th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: June 12th 2021

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Jehane Eid

Cairo University

Dr. Eid completed her BSc. (Hons., 1999) and MSs (2006) in Zoology from Cairo University. She completed her Ph.D. in Molecular Biology in 2010, and since July 2016, she has worked as an Associate Professor in Cairo University's Zoology Department. Dr. Eid teaches Molecular Biology to both under- and post-graduate students, and has supervised 11 theses (MSc and Ph.D.). She published papers regarding the genotoxic/anti-genotoxic effects of natural compounds and has a recent publication in Scientific Reports concerning the effects of the Chaga mushroom (Inonotus obliquus) on the normal development of Zebrafish (Danio rerio).

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As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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