Open access peer-reviewed Edited Volume

Drugs Modification via Co-crystallization

Aleksey Kuznetsov

Federico Santa María Technical University

A computational chemist in the areas of the computational design of novel complexes of porphyrins and studies of various compounds with pharmacological and anticorrosive applications, co-author of all-metal aromaticity discovery with h-index 21.


Akbar Ali

Government College University, Faisalabad

An organic chemist in the numerous areas of synthesis and characterization of various organic compounds with possible applications in photochemistry and as drugs, an expert in drugs modification and co-crystals preparation.


Solid-State Supercritical Fluid Infrared Spectroscopy Solubility Melting Point Bioavailability Stability Tabletability Co-Crystals NBO Analysis Intermolecular Interactions Dispersion Interactions

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About the book

Various compounds with pronounced pharmacological activity have been playing a dynamic and ever-growing role in the treatment of fatal infections such as typhus, influenza, typhoid, and malaria for a very long time and have saved the lives of millions of people. However, drug resistance is turning into one of the major problems that are rapidly getting attention synchronically with other essential dilemmas with which humankind encounters, such as a quickly growing population, scarcity of food, and environmental concerns. To cope with the growing challenge of drug resistance and to improve the quality of life, we must either synthesize novel biomedical agents or thoroughly analyze and advance the currently used drugs. It is important to mention that new medicines should be cost-effective as well as with none or almost no side effects. Besides, the stability and solubility in water and other liquids present in the human body are also important factors to be taken into account for increasing their efficiency against harmful parasites and other disease-provoking agents. One of the relatively facile and highly effective approaches to meet these requirements is the modification of existing drugs via co-crystallization with various agents, with the formation of numerous co-crystals with smaller molecules, including those of different solvents such as water and alcohols. Despite its relative easiness, when employing this approach numerous factors such as (weak) intermolecular interactions should be taken into account, because they can significantly affect structures and properties of the target co-crystals and, as a result, properties and potential applications of the drugs of interest.

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About the editor

Aleksey Kuznetsov

Federico Santa María Technical University

Dr. Aleksey Kuznetsov obtained his Ph.D. in Physical Chemistry at the Department of Chemistry and Biochemistry, Utah State University, the USA. He graduated after 3 years of doctorate studies with a specialization in Computational/Theoretical Chemistry. Since graduation, he has been researching various subareas of this field, and in 2019, after several postdoctoral and visiting professor positions in Germany, the USA, and Brazil, Dr. Kuznetsov acquired a permanent faculty position at the Department of Chemistry, Universidad Técnica Federico Santa Maria, in Santiago, Chile, where he has been working on the computational design of various complexes of porphyrins, including core-modified porphyrins, with nanoparticles, fullerenes, and graphenes, along with computational studies of various transition metal complexes, organic compounds with potential pharmacological applications, metal-fullerene complexes, compounds with anticorrosive properties, etc.

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