Open access peer-reviewed Edited Volume

Pyrophosphate Biology and Medicine - Advances, Applications and Challenges

Abdullah Al Hasan

Southeast University


Biology of Pyrophosphate Pyrophosphate-Dependent Metabolism Inositol Pyrophosphate Pathway Pathological Perspectives Calcium Pyrophosphate Deposition Vascular Calcification Medical Perspectives Epidemiology Pharmacological Perspectives Ferric Pyrophosphate Citrate Pyrophosphate Metabolites Thiamine Pyrophosphate Riboswitches Terpene Byiosynthesis

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About the book

Pyrophosphate (PPi) has long been recognized as a by-product of diverse biosynthetic reactions and was initially identified as a key endogenous inhibitor of biomineralization. PPi is synthesized from extracellular ATP by ecto-nucleotide pyrophosphatase/phosphodiesterase from extracellular ATP hydrolysis. Vascular calcification refers to the deposition of calcium phosphate, mainly in the form of hydroxyapatite crystals, in cardiovascular tissues including arteries and myocardium. It is correlated with an elevated risk of cardiovascular disease and myocardial infarction in diabetic patients and in those with chronic kidney disease. Many enzymes implicated in the metabolism of pyrophosphate have been associated with vascular calcifications. Pyrophosphate may also act as a signaling molecule to regulate gene expression. Thus, it is necessary to outline our current insight regarding pyrophosphate metabolism and how it regulates bone mineralization and inhibits harmful soft tissue calcification. Therapies based on pyrophosphate metabolism have been compelling in animal models, including renal failure, and hold hope as promising therapies to prevent vascular calcification. This work intends to summarize recent progress and future directions for the study of pyrophosphate metabolism and how it regulates bone mineralization and prevents harmful soft tissue calcification, how dysregulation of PPi results in human diseases as well as the development of novel molecules and strategies that can interrogate and manipulate the cellular actions of pyrophosphate.

Publishing process

Book initiated and editor appointed

Date completed: November 12th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: February 1st 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: April 21st 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: June 20th 2020

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About the editor

Abdullah Al Hasan

Southeast University

Abdullah Al Hasan received his MPharm degree in Pharmaceutical Chemistry at the University of Dhaka, Bangladesh. During his study, he worked on the biology of natural products at the Department of Pharmaceutical Chemistry, University of Dhaka. After his post-graduation, he got a permanent position in the Department of Pharmacy, Southeast University, Bangladesh in 2013. He established his own research group in 2016 in that department with the main objective of studying the structural biology of drug action with a particular focus on drug design and drug discovery. His team is also deeply engaged in nano-scale science and technology with a focus on targeted drug delivery and cancer research.

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