Open access peer-reviewed Edited Volume

P53 - A Guardian of the Genome and Beyond

Mumtaz Anwar

University of Illinois at Chicago

Postdoctoral Research Scientist at the Department of Pharmacology and Regenerative Medicine, College of Medicine, the University of Illinois at Chicago, USA, and a member of various scientific organizations and societies (AHA, ASPET, ASPET Young Scientists Committee, NAVBO, USCAP).

Co-editors:

Zeenat Farooq

University of Illinois at Chicago

Postdoctoral Research Associate at the University of Illinois at Chicago, USA, and author of a book and journal articles about epigenetics and chromatin remodeling. Recipient of various awards and honors including CSIR-UGC, ASRB-NET, GATE, Merit scholarship, RA ship from ICMR.

Mohammad Tauseef

Chicago State University

Assistant Professor at the Chicago State University, USA, and recipient of various awards including AHA Postdoctoral fellowship, Midwest Affiliate, Outstanding Young Investigator Travel Award, Research Recognition award, Best Teacher award, and other Postdoctoral competition category awards.

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Vijay Avin Balaji Ragunathrao

University of Illinois at Chicago

Postdoctoral Research Scientist at the Department of Pharmacology and Regenerative Medicine, College of Medicine, the University of Illinois at Chicago, USA; his research interests include tumor angiogenesis and maintenance of lung vascular homeostasis.

Covering

Gene Structure Protein Function GateKeeper Cell Cycle De-Regulation Tumorigenesis Non-Histone Protein Stem Cells Human Diseases Immune System Neurodegeneration DNA Methylation Chromatin Modifiers

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About the book

With the beginning of 21st century, interest of researchers started growing in understanding the complex phenomena of how cells renew themselves and communicate with one another. This made research into the field of cell division and cell signalling see significant progress. It is because of the fundamental cellular requirement of division and communication by the cells the research in cell signaling pathways and cell division associated proteins has always occupied a cornerstone position. Among these proteins, the protein P53 has remained the “best friend” of cellular biologists because of its amazing ability to regulate cell division and control apoptosis. P53 is the most extensively researched protein in cell biology and has been investigated in relation to cell cycle control, apoptosis, neurodegeneration, immune system and many other processes. The most well-known role of P53 remains as a tumor suppressor (gate keeper) and its de-regulation has been shown to be involved in various forms of cancer. However, with the introduction of recent technological advancements in research, role of P53 is slowly being re-written as a protein which is multi-faceted in its action.

This book talks at length about the classical roles of P53 since its discovery and navigates through its most recent and non-canonical functions, as supported by recent evidences and research across diverse fields of interest.

Publishing process

Book initiated and editor appointed

Date completed: November 6th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: December 4th 2020

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: February 2nd 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: April 23rd 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: June 22nd 2021

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Mumtaz Anwar

University of Illinois at Chicago

Mumtaz Anwar, PhD, is currently a Postdoctoral Research Scientist at the Department of Pharmacology and Regenerative Medicine, College of Medicine, University of Illinois at Chicago, Illinois, USA. Dr Anwar obtained his PhD in Cancer Biology and Molecular Epigenetics at the Faculty of Medicine, department of Gastroenterology and department of Experimental Medicine and Biotechnology, PGIMER, Chandigarh, India. His PhD thesis concerned the investigation of Wnt signaling pathway in search for new tumor prognostic and biomarkers in colorectal cancer. Dr Anwar is the author of many book chapters and journal articles about tumor markers and is involved in other scientific activities in this advanced molecular technology era. He is a member of various Scientific Organizations and societies including American Heart Association (AHA), American Society for Pharmacology and Experimental Therapeutics (ASPET), ASPET Young Scientists Committee, North American Vascular Biology Organization (NAVBO), United States and Canadian Academy of Pathology (USCAP). He is the recipient of various awards including Outstanding Young Investigator Travel Award and other Postdoctoral competition category awards. He is also an editorial board member and reviewer and reviews research articles to various scientific journals.

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