About the book
Herpesviridae is a widespread family of double-stranded DNA viruses that infect mammals, which some members of this family are the etiological agent of different diseases in humans. Several host cells' lineages are susceptible to herpesvirus infection, e.g., epithelial cells, neurons, monocytes, lymphocytes. Noteworthy, the common characteristic of Herpesviruses is to establish latency in the host cell. This lifelong infection suggests that herpesviruses have critical features to evade immunosurveillance. The knowledge about herpesvirus molecular genetics has been critical to design new therapies based on Herpes simplex vectors.
This book summarizes the main aspects of Herpesviruses infection, the key molecular mechanisms associated to latency and reactivation, mechanism related to immune evasion, immunosuppression and cellular stress, the contribution of herpesvirus (Herpes simplex type 1, Human herpevirus 6) to the neurodegenerative disease and autoimmunity, development of new drugs and vaccines against Herpesviruses, and development of gene therapy against cancer based on herpes simplex vectors.