Open access peer-reviewed Edited Volume

Herpesviridae - New Perspectives

Angello Retamal-Díaz

University of Antofagasta

Dr. Retamal-Díaz is a young scientist working in the field of virus-host interaction and has received the Best Doctoral Thesis Award 2019 at the Chilean Society for Microbiology (SOMICH) about Herpes simplex virus and Dendritic cells. He is an activist for scientific outreach and technology assessment of public policies. He is a member of the American Society for Microbiology.


MicroRNA Primary Infection Latency Reactivation Innate Immunity Adaptive Immunity CNS Inflammation Vaccine Drug Rational Design Antiviral Resistant Viruses HSV-1 Vectors Gene Therapy

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About the book

Herpesviridae is a widespread family of double-stranded DNA viruses that infect mammals, which some members of this family are the etiological agent of different diseases in humans. Several host cells' lineages are susceptible to herpesvirus infection, e.g., epithelial cells, neurons, monocytes, lymphocytes. Noteworthy, the common characteristic of Herpesviruses is to establish latency in the host cell. This lifelong infection suggests that herpesviruses have critical features to evade immunosurveillance. The knowledge about herpesvirus molecular genetics has been critical to design new therapies based on Herpes simplex vectors.

This book summarizes the main aspects of Herpesviruses infection, the key molecular mechanisms associated to latency and reactivation, mechanism related to immune evasion, immunosuppression and cellular stress, the contribution of herpesvirus (Herpes simplex type 1, Human herpevirus 6) to the neurodegenerative disease and autoimmunity, development of new drugs and vaccines against Herpesviruses, and development of gene therapy against cancer based on herpes simplex vectors.

Publishing process

Book initiated and editor appointed

Date completed: March 9th 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

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Approved chapters written in full and submitted

Deadline for full chapters: June 5th 2021

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Full chapters peer reviewed

Review results due: August 24th 2021

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Expected publication date: October 23rd 2021

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About the editor

Angello Retamal-Díaz

University of Antofagasta

Dr. Angello Retamal-Díaz is a Biochemist from the Universidad de Concepción, Chile, and a Ph.D. in Molecular Genetics and Microbiology from the Pontificia Universidad Católica de Chile. After his PhD, he performed post-doctorate, at the Millennium Institute on Immunology and Immunotherapy (Federation of Clinical Immunology Societies, FOCiS Center of Excellence) in association with the Health Command of the Chilean Army. He is currently Associated Professor in the Department of Biotechnology, Faculty of Ocean Sciences and Biological Sources, Universidad de Antofagasta, Chile. Dr. Retamal is a young researcher, he has won the prize for the best doctoral thesis at the Chilean Society for Microbiology. He has also been awarded by several prestigious institutions in Chile, as the Ministry of Economy, Chilean Government, and Daily “El Sur” gave him the award to "Leaders 2009: 50 Young people for the bicentennial". His research focuses on the host-pathogen interaction, particularly at molecular level, in the immune response against infectious agents, as well as vaccine and antiviral design. He has published articles in the Microbiology, Virology and Immunology fields and has contributed to the community has given numerous outreach conferences and has published the first Technology Assessment document from the Millennium Scientific Initiative to the Chilean Congress.

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