About the book
RNA viruses are classified according to their sense or polarity of RNA into Plus-Strand RNA viruses, Minus-Strand RNA viruses and also genome can be classified as single stranded, double stranded or fragmented. Most of RNA viruses replicate and are assembled in the cytoplasm but DNA viruses replicate and are assembled in the nucleus of the host cell. Medically important RNA viruses are; Togavirus, Bunyavirus, Flavivirus, Filovirus, Arenavirus,Rhabdovirus,Paramyxovirus, Orthomyxovirus, Coronavirus, Retrovirus, Picornavirus, Reovirus and Calicivirus. Several human diseases are caused by RNA viruses. Among RNA viruses, Flaviviridae family is considered as one of potential and emerging international public health problem in worldwide. Flavivirus genus of the Flaviviridae family comprises dengue virus, yellow fever virus, chikungunya virus, Japanese encephalitis virus, Zika virus etc. Flavivirus may manifest mild symptoms such as malaise, fever and joint pain, with a maculopapular rash commonly found on the body. However, pathogenesis mechanism causing viral diseases among the Falvivirus family has not been clearly understood and also little know about the host responses to RNA viral infection.
The main aim of this book will to understand the RNA viruses (such as Flaviviridae family), through seroprevalence status, research studies based on molecular genotyping tools by IgM/IgG, ELISA, PCR, FRNT50 and phylogenetic analysis.