Open access peer-reviewed Edited Volume


Aleksandar Jakovljevic

University of Belgrade


Aleksandra Knezevic

University of Belgrade


Human Herpesviruses Classification Virion Properties Dissemination Clinical Manifestations Diagnosis Detection Methods Prognostic Methods Therapy Epidemiology and Prevention

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About the book

More than 200 herpesviruses have been described in humans and animals. Eight of these viruses are known to infect humans: herpes simplex virus 1 (HSV-1), herpes simplex virus 2 (HSV-2), human cytomegalovirus (HCMV), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), and Human Herpesviruses 6A, 6B, and 7 (HHV-6A, HHV-6B, HHV-7), and Kaposi’s sarcoma–associated herpesvirus (also known as HHV-8).

After the primary infection of the host, herpesviruses established a persistent lifelong infection, which can be reactivated from time to time especially if the host becomes immunocompromised. The different viral species persist in different cells, whereby the cell type is the decisive factor determining latency or replication of the virus. Herpesvirus reactivation may occur spontaneously or as a result of psychosocial and physical stress, hormonal changes, infections, immunosuppressive medication, and other events impairing the host immune defense. However, the actual mechanisms that reactivate the lytic viral life cycle are unknown. Primary and/or reactivated herpesvirus infections are often asymptomatic, but they can be manifested as diseases of varying severity. The severity of an infection is determined by the interplay between the particular virus and its host, and especially on cell-mediated immunity of the host.

The objectives of this book are to provide current knowledge related to the biology of human Herpesviruses including pathogenesis, clinical manifestations, diagnosis, therapy, epidemiology and prevention.

Publishing process

Book initiated and editor appointed

Date completed: December 3rd 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: May 23rd 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: August 11th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: October 10th 2020

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Aleksandar Jakovljevic

University of Belgrade

Aleksandar Jakovljevic (born 1986) graduated in 2010 as a DDS from the University of Sarajevo, Bosnia and Herzegovina. He earned his Ph.D. in basic and clinical dental sciences related to herpesviral infection in apical periodontitis from the University of Belgrade, Serbia, in 2017. From 2012 he has been the Associate Researcher on the project entitled “Genetic control and molecular mechanisms in malignant, inflammatory and developmental pathologies of the orofacial region” (Project number 175075, financed by the Ministry of Education, Science and Technological Development of the Republic of Serbia), at School of Dental Medicine, University of Belgrade, Serbia. Since 2017 he has been the teaching assistant at the Department of Pathophysiology, Cathedra of Oral Rehabilitation, School of Dental Medicine, University of Belgrade, Serbia. He has published numerous articles in peer-reviewed international journals in the field of the etiopathogenesis of apical periodontitis and Herpesviruses. He also acts as a reviewer for a number of international journals (including International Endodontic Journal, Archives of Oral Biology, Acta Odontologica Scandinavica, Journal of Applied Oral Science, Journal of Virology, etc.) and as an external reviewer for the French Institute for Dental Research (IFRO). He has received several awards for his scientific work, including the Best young investigator at the 20th Congress of the Balkan Stomatological Society in 2015, at the 4th and 5th Congress of the Austrian Society for Endodontology in 2016 and 2018, and the 11th edition of Paul Calas Prize of the French Society of Endodontics in 2018. In 2015 and 2019 he received the prestigious awards of the European Endodontic Society – Young Investigators Research Grant for the projects entitled: “Oxidative stress biomarkers and bone resorption regulators in apical periodontitis - correlation with Epstein-Barr virus infection” and “Getting controls under control: the selection and analysis of different oral tissues as appropriate counterpart of apical periodontitis lesions”. In 2018, his paper entitled: “The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review” has been selected by the American Association of Endodontists Continuing Education Committee for inclusion on Endo On Demand CE program.

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