About the book
Alzheimer's disease (AD) is a common neurodegenerative disorders affecting most of the elderly population. The main feature of AD patients are the toxic accumulation of abeta peptide, with amyloid plaque formation, and hyperphosphorylation of tau protein with the microtubule disassembling. Most of the therapeutic approaches for this pathology are mainly focused on the disruption of amyloide plaque but no one have beneficial effects. The amyloid fragments are a proteolitic products of Amyloid precursor protein (APP) and most recent some researchers have identified as the APP over-expression, in the early phase of the pathology, is a common feature of AD pathology. The APP over-expression activate a cascade influencing also the hyperphosphorylation of tau protein leading to a complete degeneration of neurons, alteration of inflammatory response, reduction of synaptic plasticity and the involvement of cognitive deficit.
This book aims to describe all recent evidence related to AD and deeply underline all possible molecular mechanism triggering disease.