Open access peer-reviewed Edited Volume

Alzheimer's Disease

Antonella Borreca

National Research Council


RNA binding protein post translstional modification protein synthesis synaptic plasticity axon degeneration microtube disassembling Trem2 microglia activation cytokine synaptic pruning

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About the book

Alzheimer's disease (AD) is a common neurodegenerative disorders affecting most of the elderly population. The main feature of AD patients are the toxic accumulation of abeta peptide, with amyloid plaque formation, and hyperphosphorylation of tau protein with the microtubule disassembling. Most of the therapeutic approaches for this pathology are mainly focused on the disruption of amyloide plaque but no one have beneficial effects. The amyloid fragments are a proteolitic products of Amyloid precursor protein (APP) and most recent some researchers have identified as the APP over-expression, in the early phase of the pathology, is a common feature of AD pathology. The APP over-expression activate a cascade influencing also the hyperphosphorylation of tau protein leading to a complete degeneration of neurons, alteration of inflammatory response, reduction of synaptic plasticity and the involvement of cognitive deficit.

This book aims to describe all recent evidence related to AD and deeply underline all possible molecular mechanism triggering disease.

Publishing process

Book initiated and editor appointed

Date completed: December 3rd 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: May 15th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: August 3rd 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: October 2nd 2020

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Antonella Borreca

National Research Council

Antonella Borreca is a molecular biologist specialized in the field of neuroscience. She received a master degree in Biology at University of Naples and immediately after a PhD in Neuroscience. During her PhD she specialized in Neurogenetic aiming to identify new gene or new mutation in neurodegenerative disease. Then she moved in Belgium for a post doc and she specialized in molecular neuroscience, studying molecular mechanism of Fragile X Syndrome. She then returned back to Italy where she improved her career and expertise within behavioural field. Thanks to her expertise she is able to deeply analyze different aspects of neuroscience field. She participated in different international meetings and collaborated with group in Rome but also Milan, USA, etc. Actually her research is focused on the molecular mechanism of APP expression in normal and pathological condition in AD mice model (Tg2576). In particular, she analyzed the role of RNA Binding Protein (RBPs) in the APP metabolism and their regulation in APP expression, since APP is found overexpressed in AD patient with Swedish mutation (Johnston et al., 1994) but also in sporadic cases (Vignini et al., 2014; Borreca et al., 2015). She has also observed an unbalance of two specific RBPs in the AD mice model and synaptosomes of AD sporadic patient: hnRNP C and FMRP (Borreca et al., 2015). She focused the research on the role of the protein synthesis machinery in the Alzheimer disease. In particular she analyzed the protein synthesis in the early phase of the pathology and distribution of APP mRNA on polysome fractionation as well as the role of some protein synthesis molecule in the Alzheimer pathology (Borreca et al., 2017 in preparation).

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Book chapters authored 2

Books edited 1

Introducing your Author Service Manager

Mrs. Mia Vulovic

r. Hülya Şenol graduated from the Biology Department, Atatürk Education Faculty at Marmara University, Turkey in 1991. She has completed two master degrees, one in the field of Educational Sciences, Eastern Mediterranean University, Cyprus and one in Molecular Medicine, Near East University, Cyprus. Dr. Şenol holds a Ph.D. degree in Educational Administration, Management, Inspection, and Economy. She is a multidisciplinary researcher and has 28 years of teaching experience. From 1991 to 2011, she worked at many colleges in Turkey and in North Cyprus as an instructor, ISO 9001 committee member, and deputy principal. Dr. Şenol is a senior instructor in the Faculty of Arts and Sciences at Eastern Mediterranean University. She has earned many certificates about the education of trainers in Montessori education, educational sciences, and molecular medicine. Her current research interest areas are Educational Leadership, School Culture, Total Quality Management in Education, Service Quality in Education.

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