About the book
Parkinson’s disease (PD) is the second most common neurodegenerative disorder (NDD) affecting approximately 1% of the population over 50 years of age. More than 6 million individuals across the globe are suffering from PD. The death of dopaminergic neurons in the substantia nigra (SN) is the characteristic pathophysiological feature of PD. The loss of dopaminergic neurons leads to improper motor functions which are characterized by bradykinesia, tremors, and rigidity. Other non-motor symptoms such as sleep disturbances, constipation, cognitive decline, depression, fear, anxiety, bladder problems, weight changes, fatigue and loss of energy, hypotension, and sexual problems are also characterized in patients with PD.
The proposed book will aim to provide a comprehensive account of current knowledge on:
1. Role and utility of animal models to understand the pathophysiology of PD and screening therapeutic molecules of dopaminergic neuroprotection
2. Importance of epidemiological studies and available therapeutic strategies for PD
3. Mechanistic insights into dopaminergic neuroprotection/neurodegeneration relating to PD
The present project concerns “reducing the burden of disease” which is the prime aim of biomedical research.
