Open access peer-reviewed Edited Volume

Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials

Sarat Chandra Yenisetti

Nagaland University

Dr. Sarat obtained post-doctoral training in neurogenetics from the University of Regensburg, Germany, and the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH), Bethesda, USA. He follows Drosophila approaches to understand dopaminergic neurodegeneration and identification of therapeutic targets for neuroprotection; knowledge of which may help to reduce the burden of Parkinson’s disease (PD) in humans.


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About the book

Parkinson’s disease (PD) is the second most common neurodegenerative disorder (NDD) affecting approximately 1% of the population over 50 years of age. More than 6 million individuals across the globe are suffering from PD. The death of dopaminergic neurons in the substantia nigra (SN) is the characteristic pathophysiological feature of PD. The loss of dopaminergic neurons leads to improper motor functions which are characterized by bradykinesia, tremors, and rigidity. Other non-motor symptoms such as sleep disturbances, constipation, cognitive decline, depression, fear, anxiety, bladder problems, weight changes, fatigue and loss of energy, hypotension, and sexual problems are also characterized in patients with PD.

The proposed book will aim to provide a comprehensive account of current knowledge on:
1. Role and utility of animal models to understand the pathophysiology of PD and screening therapeutic molecules of dopaminergic neuroprotection
2. Importance of epidemiological studies and available therapeutic strategies for PD
3. Mechanistic insights into dopaminergic neuroprotection/neurodegeneration relating to PD

The present project concerns “reducing the burden of disease” which is the prime aim of biomedical research.

Publishing process

Book initiated and editor appointed

Date completed: March 4th 2022

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: July 4th 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: September 22nd 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: November 21st 2022

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Sarat Chandra Yenisetti

Nagaland University

Dr. Sarat Chandra Yenisetti is an Associate Professor and Head of Drosophila Neurobiology Laboratory in Department of Zoology, Nagaland University (Central), Nagaland, India. He completed M.Sc. from Bangaluru University, India and was awarded a Ph.D. from Kuvempu University, India. Dr. Sarat obtained post-doctoral training in 'modelling Parkinson’s disease using Drosophila” from Neurogenetics, National Institute of Neurological Disorders and Stroke (NINDS) of National Institutes of Health (NIH), Bethesda, USA and University of Regensburg, Germany. His laboratory, funded through multiple research grants from Department of Biotechnology (DBT), India, University of Grants Commission (UGC), India and Department of Science and Technology (DST), India, focuses on Drosophila approach to understand Parkinson's Disease associated neurodegeneration as well as identification of novel therapeutic targets which may help to reduce the burden of PD in human.

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