Open access peer-reviewed Edited Volume

Primary Immunodeficiency

Hridayesh Prakash

Amity University

Dr. Hridayesh Prakash is a Fellow of the Royal Society of Biology, London. Currently, he is an Associate Professor at the Virology and Immunology Department, Amity University, India. His specializations are Tumor Immunology / Immunotherapy (lung and pancreatic cancer) and Cell-based Immunotherapies, Host Apoptosis regulation, Signal Transduction, Pulmonary Infection Biology, and Radiation Biology.


Common Variable Immune Deficiency Ataxia Telangiectasia Wiskott-Aldrich Syndrome DiGeorge Syndrome XLP Hematological Malignancies Latent infection (H .pylori) Complement Deficiencies HLA Mimicry Immunopathologies Viral Infection HPV Infections

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About the book

Primary immunodeficiencies (PID) are the genetic anomalies/disorders which are characterized by the jeopardized immune system in organisms. Primary immune deficiencies are genetic in origin and may result from a single genetic defect. These may be caused by recessive or dominant inheritance. Some are latent and require a certain environmental trigger to become manifest, like the presence in the environment of a reactive allergen. Other problems become apparent due to the aging of bodily and cellular maintenance processes. Most of the primary immune deficiencies are genetically ablated and diagnosed in children who are in their initial span of age. So far more than several hundred PIDs have been identified until recently which are associated with one of other genetic/somatic factors. Interestingly, the majority of them are very rare. According to WHO data about 1 in 1000 children is born with primary immunodeficiency.

As mentioned earlier, genetically ablated or functionally poor immune profile of the immune-deficient person/patient predisposes them highly susceptible to recurring infections, auto-immunity, tumors and malfunctioning of organs. Although most of PID's are having no stable treatment, due to advancement in the biotechnological approach, new treatment modalities are emerging which has shown promise for the clinical management of these inevitable disorders. Because of this, there is a dire need for newer research modality like the use of stem cell (HSCT) and/or gene therapies which are paramount for the modification of null immune system in PID patients.

One of the common manifestations of primary immunodeficiency includes recurrent or persistent infections or delay in the resolution of the infection which might inflict PID. Among various organs which are affected by PID is the skin, heart, facial and skeletal system.

Given the above, the main purpose of this book is to discuss various immune genetic and molecular aspects of PID. The emphasis of this book is to discuss various interventional modalities for the management of PID and cover the translational spectrum of disease management.

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Book initiated and editor appointed

Date completed: October 13th 2020

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Deadline for chapter proposals: November 10th 2020

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Deadline for full chapters: January 9th 2021

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Review results due: March 30th 2021

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Book compiled, published and promoted

Expected publication date: May 29th 2021

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About the editor

Hridayesh Prakash

Amity University

Hridayesh Prakash, Ph.D is Associate Professor at Virology and Immunology Department, Amity University, India. Before starting his current position, he was Ramanujan Professor at University of Hyderabad during 2013-2017 and postdoctoral fellow in Germany during 2005-2013. His specializations are Tumor Immunology / Immunotherapy (lung and pancreatic cancer) and Cell based Immunotherapies, Host Apoptosis regulation, Signal Transduction, Pulmonary Infection Biology, Radiation Biology. His major research area is Immunotherapy of persistent Respiratory Infections and Gastric Cancer. He is unraveling therapeutic potential of macrophage against solid and established tumors and their contribution in various cancer directed interventions like radio / immune therapies. His second major interest is to understand how certain pathogens like H. pylori, Chlamydia and Mycobacteria sabotage host immunity with special emphasis on macrophage during chronic and persistent infections. Dr. Prakash has amply demonstrated that macrophages indeed represent potential target cell populations for translational medicine. He was able to demonstrate that adoptive transfer of tumor bearing mice with iNOs+ M1 macrophages offers an easy substitute of cumbersome high dose radiotherapy for the eradication of established, solid and refractory tumors of pancreas which is curse and death statement for the humankind. Within frame of this, he is also unraveling the impact of exchange of TAM with M1 macrophage on persistent infection driven cancer (adenocarcinoma) as well. He has published 39 papers including 3 book chapters. He received Young Scientist Award from Deference Research and Development organization, Govt of India and Ramanujan fellow award from Department of Science and Technology, Govt of India. Other than this Dr. Prakash is serving as member of Indian and German Immunology society. He is also serving as editorial board member of several international peer reviewed journals like F. Immunology, F. Microbiology. He has served as external reviewer for Austrian and Romanian Research Council and was a recipient of Travel from European society of Dermatological Research. Recently he has been elected as Fellow of Royal Society of Biology, London which is a caveat award conferred to him.

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