About the book
Monoclonal antibodies are antibodies that are cells derived by cell division from a single ancestral cell, which means they are class of antibodies made by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies can have monovalent affinity, when they bind to the same epitope. Bispecific monoclonal antibodies can also be engineered, by increasing the therapeutic targets of one single monoclonal antibody to two epitopes. Monoclonal antibodies can target various proteins that influence cell activity such as receptors or other proteins present on the surface of cells. Monoclonal antibodies can be used to detect the presence of some proteins, which is applicable in some immunological tests such as Western blot and immuno dot blot tests. Monoclonal antibodies are one of the fastest growing biological therapeutic agents, used to treat cancers, and certain types of autoimmune diseases, such as arthritis, systemic lupus erythematosus, ankylosing spondylitis, multiple sclerosis, and inflammatory bowel disease. They can be used to prevent acute rejection of kidney transplants and can be useful in treatment of moderate-to-severe allergic asthma. Some side effects could be expected for monoclonal antibodies.
In this book, we welcome all proposals regarding monoclonal antibodies, from its production to its application in diagnostic tests and treatment opportunities.