Open access peer-reviewed Edited Volume

Monoclonal Antibodies

Nima Rezaei

Tehran University of Medical Sciences

Dr. Rezaei is listed among the World top 1% scientists by the Essential Indicators of Science. He has authored more than 700 publications, including five books to receive the 10th, 16th, and 17th Avicenna Festival awards for best book of the year for; "Primary Immunodeficiency Diseases", Immunology of Aging" and "Cancer Immunology" series. His h-index of 54 is a clear indicator of his merit and impact as a researcher.


Hybridoma Development Novel Mab Development Technology Purification Antibody Heterogeneity Recombinant Chimeric Antibodies Human Antibodies Diagnostic Tests Monoclonal Antibody Therapies Side Effects Allergy Anaphylaxis

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About the book

Monoclonal antibodies are antibodies that are cells derived by cell division from a single ancestral cell, which means they are class of antibodies made by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies can have monovalent affinity, when they bind to the same epitope. Bispecific monoclonal antibodies can also be engineered, by increasing the therapeutic targets of one single monoclonal antibody to two epitopes. Monoclonal antibodies can target various proteins that influence cell activity such as receptors or other proteins present on the surface of cells. Monoclonal antibodies can be used to detect the presence of some proteins, which is applicable in some immunological tests such as Western blot and immuno dot blot tests. Monoclonal antibodies are one of the fastest growing biological therapeutic agents, used to treat cancers, and certain types of autoimmune diseases, such as arthritis, systemic lupus erythematosus, ankylosing spondylitis, multiple sclerosis, and inflammatory bowel disease. They can be used to prevent acute rejection of kidney transplants and can be useful in treatment of moderate-to-severe allergic asthma. Some side effects could be expected for monoclonal antibodies.

In this book, we welcome all proposals regarding monoclonal antibodies, from its production to its application in diagnostic tests and treatment opportunities.

Publishing process

Book initiated and editor appointed

Date completed: July 8th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: September 27th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: December 16th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: February 14th 2021

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Nima Rezaei

Tehran University of Medical Sciences

Professor Nima Rezaei gained his medical degree from Tehran University of Medical Sciences and subsequently obtained an MSc in Molecular and Genetic Medicine and a PhD in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also spent a short-term fellowship studying pediatric clinical immunology and bone marrow transplantation at Newcastle General Hospital.  Professor Rezaei is now Full Professor of Immunology and Vice Dean of International Affairs, School of Medicine, Tehran University of Medical Sciences, and the co-founder and Deputy President of the Research Center for Immunodeficiencies. He is also the founding president of Universal Scientific Education and Research Network. Professor Rezaei has been the director of more than 50 research projects and has designed and participated in several international collaborative projects. He is an editorial assistant or board member for more than 30 international journals. He has edited more than 10 international books, presented more than 400 lectures/posters in congresses/meetings, and published more than 700 articles in international scientific journals.

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Book chapters authored 4

Books edited 5

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As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copy-editing and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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