Open access peer-reviewed Edited Volume

Circadian Rhythm - New Insights Into the Physiological and Pathological Implications

Cristina Manuela Drăgoi

Carol Davila University of Medicine and Pharmacy

As a researcher with over 200 publications in the field of Drugs Biochemistry and Neuroendocrinology Nutritional Biochemistry, Dr. Dragoi’s research is focused on Melatonin as the major circadian regulatory molecule, and revealing Melatonin's actions on major physiological processes.


Alina Crenguţa Nicolae

Carol Davila University of Medicine and Pharmacy

A researcher in the pharmaceutical field, Dr. Nicolae is the managing editor of FARMACIA journal, member of the Romanian Pharmaceutical Society, and author of over 50 publications among which 'P-glycoprotein and the development of multidrug resistance' represents a complete book revealing the biochemical mechanisms underlying the vast and intricate process of multidrug resistance that occurs in living cells.

Ion Bogdan Dumitrescu

Carol Davila University of Medicine and Pharmacy

An enthusiastic researcher in the field of 3D printing applied for pharmaceutical and medical uses. Highly active in the pharmaceutical field, Dr. Dumitrescu acts as the managing editor and webmaster for the online edition of Farmacia Journal, Congress Chairperson, and Publications Officer for the European Pharmaceutical Students Association.


Nictemeral Disruptors Molecular Circadian Clock Jet Lag Shift Work Environmental Factors Distress Suprachiasmatic Nucleus Zeitgeber Endogenous Oscillators Modulatory Effect Regulatory Genes Endocrine Signaling

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About the book

Circadian rhythms play fundamental roles in adjusting and synchronizing all physiological processes from cell differentiation and development to complex regulatory endocrine or immune mechanisms. The consequence of any circadian misalignment is immediately perceived as a major imbalance, having profound echoes at the pathologic level, multiple systemic diseases being closely related to nictemeral distress. Chronobiology is becoming a rapidly evolving research field at the intersection of biochemistry, medicine, and pharmacy, all in regard to illuminating the pathway to prevention and treatment of circadian rhythm-related pathologies. Considering the integrative role of the human being in the environmental complexity, exerted by the circadian rhythm, it is of tremendous interest to highlight the latest scientific information, gather all logical opinions, and debate on the contradictory hypotheses and obtained results.

This book aims to provide a comprehensive review of the present state-of-the-art in nictemeral science, starting from the basic explanatory aspects considering physiological details and molecular mechanistic pathways and up-grading the discussion to endogenous and exogenous disruptors and their immediate pathogenic effects at different levels, further detailing clinical and therapeutic approaches.

Publishing process

Book initiated and editor appointed

Date completed: September 7th 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: October 5th 2021

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: December 4th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: February 22nd 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: April 23rd 2022

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Cristina Manuela Drăgoi

Carol Davila University of Medicine and Pharmacy

CRISTINA MANUELA DRĂGOI is associate professor at the Department of Biochemistry, Faculty of Pharmacy, University of Medicine and Pharmacy 'Carol Davila', Bucharest, Romania. She has professional and academic experience in drugs molecular mechanisms, in assessing therapeutic effects on antioxidant processes and endogenous indoles modulatory actions. She has been fascinated by melatonin, the major circadian regulatory molecule, the pineal hormone, which she has studied under different circumstances, assessed its interactions with DNA, performed research on its effects in association with other therapeutic agents, using different animal models and cell lines. Her scientific interest focuses on revealing melatonin's actions on major physiological processes, as pregnancy or aging, determining its modulatory abilities in different stages of fetus evolution, in healthy aging mechanisms and in preventing neurodegeneration. This captivating subject of applied biochemistry in drug research is the core of her scientific research projects, underlying the tremendous perspectives of chronobiology into clinical practice. Mrs. Drăgoi has a great interest in nutrition strategies applied in the clinical field, modulating the energy metabolism in cancerous states, mitochondrial and neurological diseases. The field of nutrition has been one of her active concerns, elaborating a series of scientific papers in this field.

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