About the book
Circadian rhythms play fundamental roles in adjusting and synchronizing all physiological processes from cell differentiation and development to complex regulatory endocrine or immune mechanisms. The consequence of any circadian misalignment is immediately perceived as a major imbalance, having profound echoes at the pathologic level, multiple systemic diseases being closely related to nictemeral distress. Chronobiology is becoming a rapidly evolving research field at the intersection of biochemistry, medicine, and pharmacy, all in regard to illuminating the pathway to prevention and treatment of circadian rhythm-related pathologies. Considering the integrative role of the human being in the environmental complexity, exerted by the circadian rhythm, it is of tremendous interest to highlight the latest scientific information, gather all logical opinions, and debate on the contradictory hypotheses and obtained results.
This book aims to provide a comprehensive review of the present state-of-the-art in nictemeral science, starting from the basic explanatory aspects considering physiological details and molecular mechanistic pathways and up-grading the discussion to endogenous and exogenous disruptors and their immediate pathogenic effects at different levels, further detailing clinical and therapeutic approaches.