About the book
This book will provide an extensive overview of recent advances obtained from secretome analysis with regard to cardiovascular disease mechanisms, potential biomarkers, pathophysiological effects and therapeutical aspects of cell secretome. Secreted proteins are involved in a myriad of cell communication processes.
The aims of this book are following:1) This book will describe in detail the basics aspects of cell secretome. We will focus on the role of secretory protein-induced signal transduction in cell fate processes of proliferation, growth, migration, matrix remodeling, and invasion. It will be underlined that secretome involves protein (and not only) release via several distinct secretion pathways: either classical constitutive, basal or regulated secretion, secretion from unconventional pathways and/or exosome secretions. 2) Key aspects about methodology of identification of secretome proteins and novel technologic and bioinformatics advances of secretome analysis will be summarized. 3) We will focus on the biological significance of secretome proteins in vascular microenvironment in health and under different cardiovascular conditions. Secretome biomarkers in cardiovascular diseases will be overviewed, with focus on their roles on diagnostic, prognostic and therapeutics. 4) We will highlight important pathological effects of exosomes in cardiovascular disease. 5) Overall, the book will discuss current research directions characterizing vascular pathology conditioned secretomes, their regulation and therapeutic pursuit.
This book aims to be a reference for cell biology researchers and for medical health professionals.