Open access peer-reviewed Edited Volume

Secretomics

Luiza Rusu

The Ohio State University Wexner Medical Center

A medical scientist (MD, Ph.D.) from the University of Illinois at Chicago, best known for her studies on endothelial cell G protein signaling in hemostasis and thrombosis. A Member of the American Heart Association and holder of a registered patent.

Covering

Proteomics Secretome Secretory Pathways Signal Transduction Secretome Analysis Cargo Profiling Antibody Microarray Secretome Biomarkers Therapeutics Exosomes Pathological Implications of Exosomes Pharmacological Secretion Inhibition

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About the book

This book will provide an extensive overview of recent advances obtained from secretome analysis with regard to cardiovascular disease mechanisms, potential biomarkers, pathophysiological effects and therapeutical aspects of cell secretome. Secreted proteins are involved in a myriad of cell communication processes.

The aims of this book are following:1) This book will describe in detail the basics aspects of cell secretome. We will focus on the role of secretory protein-induced signal transduction in cell fate processes of proliferation, growth, migration, matrix remodeling, and invasion. It will be underlined that secretome involves protein (and not only) release via several distinct secretion pathways: either classical constitutive, basal or regulated secretion, secretion from unconventional pathways and/or exosome secretions. 2) Key aspects about methodology of identification of secretome proteins and novel technologic and bioinformatics advances of secretome analysis will be summarized. 3) We will focus on the biological significance of secretome proteins in vascular microenvironment in health and under different cardiovascular conditions. Secretome biomarkers in cardiovascular diseases will be overviewed, with focus on their roles on diagnostic, prognostic and therapeutics. 4) We will highlight important pathological effects of exosomes in cardiovascular disease. 5) Overall, the book will discuss current research directions characterizing vascular pathology conditioned secretomes, their regulation and therapeutic pursuit.

This book aims to be a reference for cell biology researchers and for medical health professionals.

Publishing process

Book initiated and editor appointed

Date completed: November 16th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: December 14th 2020

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: February 12th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: May 3rd 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: July 2nd 2021

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Luiza Rusu

The Ohio State University Wexner Medical Center

Luiza Rusu is a visiting scientist at the University of Illinois at Chicago and the Ohio State University. A medical doctor from Bucharest, Romania, she received her PhD in Pharmacology from the University of Illinois at Chicago in 2013 and then worked as postdoctoral researcher at University of Illinois at Chicago and at Ohio State University. She is best known for her studies on endothelial cell G protein signaling in hemostasis and thrombosis. Her interests include understanding the pathophysiological role of endothelial cell vWF secretion in the severe endothelial dysfunction syndrome (SEDS). She was granted NIH and AHA awards during her graduate and postdoctoral studies. Dr Rusu published several peer-reviewed papers and served as guest reviewer for international journals, and she is the holder of a registered patent on the effects of a novel inhibitor of vWF secretion on thrombosis, organ failure, and survival.

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Book chapters authored 1

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Introducing your Author Service Manager

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As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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