Open access peer-reviewed Edited Volume

Neuromodulation - Guiding the Advance of Research and Therapy

Denis Larrivee

Loyola University Chicago


Epilepsy Dystonia Deep Brain Stimulation Oscillatory Interaction Transcranial Magnetic Stimulation (TMS) Transcranial Direct Current Stimulation (tDCS) Substance Abuse Multiple Sclerosis Ephaptic Transmission Weak Brain Electrical Fields Psychiatric Diseases Motor Rehabilitation

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About the book

Neuromodulatory devices are experiencing rapid growth, driven by an expansion in clinical applications, an evolution in deep brain stimulation procedures, and the development of novel, non-invasive technological options. These advances are promising for heretofore intractable or marginally tractable cognitive diseases and for adjunct therapies such as substance abuse. Early uses of deep brain stimulation (DBS) for the treatment of Parkinson's disease, for instance, have now moved from open to closed loop procedures that are employed in a widening range of etiopathologies, including not only the movement diseases, e.g., essential tremor and dystonia, but even psychiatric diseases like schizophrenia and bipolar disorder. Complementing DBS are new non-invasive magnetic technologies that can directly modulate cortical activity. Termed transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), these hold promise for neurorehabilitative and addiction therapies. Notwithstanding the increase in technological and therapeutic options, however, neuromodulation continues to raise questions about its mechanisms of action and the efficacy of its treatment. The role of high frequency stimulation of DBS and that of ephaptic field effects in TMS in modulating cortical and non-linear oscillatory dynamics, for example, remain notable mechanistic uncertainties that impinge on technology and treatment design. This book will highlight not only the promise of progressive advances in neuromodulation but also review evidence about its premises that can guide technology design for a new generation of treatment options.

Publishing process

Book initiated and editor appointed

Date completed: August 9th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: August 30th 2019

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: October 29th 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: January 17th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: March 17th 2020

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Denis Larrivee

Loyola University Chicago

Dr. Denis Larrivee is a Visiting Scholar at the Mind and Brain Institute, University of Navarra Medical School and Loyola University Chicago and has held professorships at the Weill Cornell University Medical College, NYC, and Purdue University, Indiana. A former fellow at Yale University's Medical School he received the Association for Research in Vision and Ophthalmology's first place award for studies on photoreceptor degenerative and developmental mechanisms. He is the editor of a recently released text on Brain Computer Interfacing with InTech Publishing and an editorial board member of the journals Annals of Neurology and Neurological Sciences (USA) and EC Neurology (UK). An International Neuroethics Society Expert he is the author of more than 70 papers and book chapters in such varied journals/venues as Neurology and Neurological Sciences (USA), Journal of Neuroscience, Journal of Religion and Mental Health, and IEEE Explore. In 2018 he was a finalist in the international Joseph Ratzinger Expanded Reason award.

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