Open access peer-reviewed Edited Volume

Cancer Stem Cells

Kate Rygiel

Medical University of Silesia (SUM)


Self-renewal Differentiation Tumorigenesis Mesenchymal Stem Cells Epithelial-to-Mesenchymal Tumor Microenvironment Clinical Practice Wnt Pathway Notch Pathway Circulating Tumor Cells Research Therapy

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About the book

Malignant tumors consist of various cancer cell types, contributing to tumor heterogeneity. Cancer Stem Cells (CSCs) are a subpopulation of such cells, characterized by the stem cell features (such as self‐renewal, differentiation, and ability to recapitulate the parental tumor upon transplantation into a host). CSCs have been associated with negative clinical outcomes, mostly because of their contribution to cancer initiation, progression, resistance to conventional anticancer therapy (e.g., chemotherapy and radiation therapy), metastasis, and recurrence. The aim of this book is to concisely summarize current and emerging research efforts focused on CSCs, as potential diagnostic and therapeutic targets, for improving the outcomes patients with the most refractory cancers. This overview will highlight an impact of Mesenchymal Stem Cells (MSCs) (a population of CSCs that can differentiate into mesodermal cells) on the tumor development and progression, via their effects on Epithelial‐to‐Mesenchymal Transition (EMT), angiogenesis, resistance to treatment, and metastatic spread. Furthermore, since MSCs may also suppress cancer cells, the mechanisms that govern the pro‐and anticancer effects of MSCs will be explained. In addition, this collection will review the key CSC signaling pathways, and some innovative strategies (e.g., targeted therapies, immunotherapy, and epigenetic approaches), aimed at expanding the therapeutic armamentarium for patients with difficult to treat malignancies. This book will also serve as an updated resource for the CSC research community. Hopefully, it will facilitate translation of recent progress in CSCs research into clinical practice, providing some potential solutions to unmet therapeutic needs in oncology.

Publishing process

Book initiated and editor appointed

Date completed: September 27th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: December 17th 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 6th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 5th 2020

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Kate Rygiel

Medical University of Silesia (SUM)

Dr. Katarzyna Anna Rygiel, M.D., Ph.D., has a background in primary care and medical research/education. She is a graduate of the Medical University of Silesia (SUM) in Poland, and she holds a certificate in Clinical Trials Design and Management from the University of California (UCSD), U.S., where she completed her research training. Her professional interests are focused on cardio-oncology, immuno-oncology, psycho-oncology, cardio- metabolic diseases, psychosomatic diseases, stress management, lifestyle modification, human aging, quality of life, patient education, and interdisciplinary team collaboration. She authored over 50 articles in various international medical journals and three books.

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Book chapters authored 2

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As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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