Open access peer-reviewed Edited Volume

Astrocytes in Brain Communication and Disease

Denis Larrivee

Loyola University Chicago

A leading researcher in global brain function, Dr. Larrivee is an expert panel member on the IEEE sponsored, medical neurotechnology ethics framework, editor-author of 5 books, and the author of 95 publications.


Astrocyte Morphogenesis Synaptic Plasticity Synaptic Shielding Reactive Astrogliosis Astroglial Asthenia ALS Huntington's Disease Alzheimer’s’ Disease Nfkb Activation JAK-STAT3 Pathway Astrocyte Therapies Thrombospondin

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About the book

The neuron-centered view of the brain and spinal cord function and disease is no longer unassailable. It is increasingly apparent that non-neuronal cellular constituents, once regarded as solely homeostatic and ancillary, share with neurons key roles affecting brain communication, including neuroplastic modulation, synapse formation, alteration, and signal coherency. Of these cells, astrocytes are the most abundant, comprising nearly five times the number of neurons present in the brain. All brain synapses, moreover, include astrocytes, which envelope the synaptic junction to form a distinctive tri-partite structure regarded as the operational unit of the synaptic cell to cell communication. Current evidence indicates that in addition to their homeostatic roles, astrocytes complement the fast form of communication characteristic of neurons, by modulating key parameters affecting transmission and promoting slower communication forms like the LTP and LTD, oscillatory patterning, and brain waves. As such astrocytes are now being considered as critical elements in the etiology of many neurological brain diseases, from epilepsy and psychiatric diseases, degenerative diseases like Alzheimer’s and ALS, to stroke and trauma. Huntington's disease, for example, is characterized by a progressive increase in reactive astrocytes with hypertrophic soma throughout the brain striatum. This book will review the current state of the field, identifying novel features that enable these critical cells to contribute to cognitive function and that give rise to etiopathology when they are impaired.

Publishing process

Book initiated and editor appointed

Date completed: February 11th 2022

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: June 13th 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: September 1st 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: October 31st 2022

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About the editor

Denis Larrivee

Loyola University Chicago

Dr. Denis Larrivee is a visiting scholar at the Mind and Brain Institute, Las Vegas; University of Navarra Medical School, Spain; and Loyola University Chicago. He has held professorships at Weill Cornell University Medical College, NYC, and Purdue University, Indiana. A former fellow at Yale University\'s Medical School Dr. Larrivee received the Association for Research in Vision and Ophthalmology\'s first-place award for studies on photoreceptor degenerative and developmental mechanisms. He is the chief editor of several medical and scientific texts, including topics on brain- computer interfacing, Alzheimer’s disease, neuromodulation and neurostimulation procedures, neuroethics, and sleep pharmacotherapies. He is an editorial board member of the journals Annals of Neurology and Neurological Sciences and EC Neurology. An International Neuroethics Society Expert he is the author of more than ninety papers and book chapters in such varied journals/venues as Neurology and Neurological Sciences, Journal of Neuroscience, Journal of Religion and Mental Health, and IEEE Explore. In 2018 he was a finalist in the international Joseph Ratzinger Expanded Reason Award sponsored by the Francis Vittorio University of Madrid.

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Book chapters authored 6

Books edited 5

Introducing your Author Service Manager

Ms. Elena Vracaric

As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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