Open access peer-reviewed Edited Volume

Hypothalamic-pituitary-adrenal Axis

Frank Ho-Yin Lai

Hong Kong Polytechnic University


Maria Uscinska

University of Turin


HPA axis activity glucocorticoid activity regulation endocrine circuit hippocampus cortisol allostatic load epigenetics of HPA axis dysregulated HPA axis neuropsychiatric illness psychopathology cognition

Register your interest in contributing to this book

Collaborate with our community and contribute your knowledge.

Register here

Deadline Extended: Open for Submissions

About the book

Survival in ever-changing environmental context hinges on the ability of an organism to adapt to various homeostatic challenges. Deeply rooted in evolutionary history, the hypothalamic-pituitary-adrenal (HPA) axis represents a primary physiological system that has been maintained by natural selection and conserved among species to promote adaptation and optimize survival. Therein, a healthy homeostatic response prompts a coordinated cascade of protective events across the metabolic, cardiovascular, immune, reproductive, and central nervous systems to mobilize the body’s resources to adapt to environmental shifts and to disengage quickly in appropriate contexts. Conversely, dysregulation, over-activity or inefficient termination of the axis may lead to a series of cascading failures across multiple physiological systems, amounting to aberrant neural and behavioural outputs. In this view, the HPA axis is currently the most researched biomarker of a varied set of physical and neuropsychiatric disorders, as well as a potential candidate for novel treatment strategies. This book intends to bring together latest developments in multidisciplinary research, presented by experts in the field to shed a critical light on the role of the HPA axis in human health and disease. 

Publishing process

Book initiated and editor appointed

Date completed: August 14th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: November 3rd 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: January 22nd 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: March 22nd 2020

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Frank Ho-Yin Lai

Hong Kong Polytechnic University

Dr Lai is the Assistant Professor of Department of Rehabilitation Sciences of the Hong Kong Polytechnic University. Before he commenced his academic career, Dr Lai has been working in the Hospital Authority (HA) of Hong Kong for more than twenty years. He has ample experience in teaching, administration, clinical service and research which covered field of psychiatric and physical rehabilitation. Most importantly, he has been working actively in clinical research throughout these years. He had been appointed as the keynote presenter for a number of international conferences, e.g. the 15th International Conference and Exhibition on Alzheimer’s Disease, Dementia and Ageing. Dr Lai is an active researcher in behavior assessment and intervention. Moreover, he is council member of the Chinese Dementia Research Association.

View profile

Book chapters authored 0

Books edited 0

Introducing your Author Service Manager

Ms. Diana Cop

Ask a question

Book will be abstracted and indexed in