Open access peer-reviewed Edited Volume

Human Teeth – Structure and Composition of Dental Hard Tissues and Developmental Dental Defects

Ana Gil De Bona

The Forsyth Institute

A researcher from Forsyth Institute, USA, affiliated with Harvard School of Dental Medicine, focused on understanding the changes in tooth enamel in healthy and defective teeth to find better diagnostics tools and treatment approaches.


Hakan Karaaslan

The Forsyth Institute

A researcher from Forsyth Institute, USA, currently investigating developmental dental defects, in particular molar incisor hypomineralization. As a clinician, he also seeks to translate basic science learnings into finding clinical therapeutics.


Human Dental Hard Tissues Ultrastructure Chemical Composition Developmental Dental Defects Etiology Hypomineralization and Hypoplasia Fluorosis Proteomics Genomics Diagnostic Tools Biomaterials Clinical Practice

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About the book

The unique tissues of human teeth, enamel and dentin, have been studied by the scientists to understand their structure, physical and chemical properties and the developmental machinery behind these extraordinary properties. During the developmental process, genetic, environmental factors or the interplay between these may cause defects on dental hard tissues, impairing their biology and function. These defects have long been studied to provide better dental care and to find novel treatment options. Understanding the mechanical, chemical and structural differences in developmental dental defects is also crucial for routine dental practice as many of these lesions do not have pathognomonic properties.

In this book, we will concentrate on the qualitative and quantitative properties of the sound enamel and dentin and as well as the affected human tooth structures. This publication aims to address clinicians, researchers and students to further their knowledge on the subject. We also hope to bring together preclinical and clinical work together for the translation of research ameliorating clinical care.

Publishing process

Book initiated and editor appointed

Date completed: October 14th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: November 11th 2020

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: January 10th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 31st 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 30th 2021

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About the editor

Ana Gil De Bona

The Forsyth Institute

Dr. Ana Gil de Bona obtained her PhD in Molecular Biology and Microbiology from Complutense University of Madrid, Spain. Her research mainly focused on the study of the proteomic profile of the extracellular vesicles and the secretome in virulent and avirulent strains of Candida albicans. She continued her scientific career in the University of Massachusetts Medical School, USA, working in yeast genetics and proteomics. Her current research at the Forsyth Institute, USA, affiliated with Harvard School of Dental Medicine, is focused on understanding the changes in tooth enamel in healthy and defective teeth to find better diagnostics tools and treatment approaches. She has authored peer-reviewed research articles, reviews and has presented her work to national and international scientific meetings.

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Book chapters authored 1

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