About the book
Vasculitis and vasculopathy may arise from a primary or secondary cause, which often makes the workup and diagnosis challenging. Vasculopathy is a general term used to describe any disease affecting blood vessels. It includes vascular abnormalities caused by degenerative, metabolic and inflammatory conditions, embolic diseases, coagulative disorders, and functional disorders such as posteri or reversible encephalopathy syndrome. The etiology of vasculopathy is generally unknown and the condition is frequently not pathologically proven. Vasculitis, on the other hand, is a more specific term and is defined as inflammation of the wall of a blood vessel. The difference is subtle but important to distinguish since there are divergent diagnoses and treatments for vasculitis and vasculopathy. The impact of vasculitis may be short-lived or can result in long-term harm to the vasculature if not treated. There are many types of vasculitis, and they vary significantly in symptoms, severity and duration. Most types of vasculitis are fairly uncommon, and the causes of the condition are not clear. Vasculitis can affect people of both genders and of all ages. In entities characterized by a vasculopathy, the process seems that of a primary endothelial injury. Such diseases (e.g., thrombotic microangiopathy, scleroderma, and dermatomyositis) are characterized by an apparent endothelial-mesenchymal transition that often results in lumenal occlusion. Finally, this book will aim to provide an overview of the pathogenesis, clinical manifestations and novel treatment options in vasculitis and vasculopathy from the perspective of rheumatologists, nephrology, pediatricians, neurologists, radiologists, and other specialists. Ultimately, this large area requires a multidisciplinary approach.