Open access peer-reviewed Edited Volume

Childhood Histiocytosis - Recent Advances and Newer Perspectives

Sneha Tandon

University Hospital Southampton NHS Foundation Trust


Olga Slater

Great Ormond Street Hospital Children's Charity


Childhood Histiocytic Disorders Juvenile Xanthogranuloma Erdheim -Chester Disease Rosai Dorfman Disease Hemophagocytic Lymphohistiocytosis Endocrinological Complications CNS LCH and Neurodegeneration Histiocytic Disorders Registries Late Effects and Sequelae of LCH Second Malignant Neoplasm Peripheral Blood BRAF Histiocytosis

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About the book

This book will aim to provide a comprehensive overview of childhood LCH. It will cover the epidemiology, clinical features, and prognostic factors. The chapters on molecular genetics and the recent advances in pathogenesis will outline the various gene mutations and molecular pathways involved in LCH pathogenesis. Newer biomarkers are being developed both for diagnosis /prognosis and disease monitoring in LCH and will be discussed in one of the chapters. The book will also provide a comprehensive review of the treatment strategies, both in the frontline as well as relapse/reactivation settings. Additional aspects covered will include the endocrine complications, CNS neurodegeneration and late effects of LCH therapy. Lastly, the book will also provide an overview of the recent advances in the treatment of LCH including recent and current trials, as well as targeted therapy as well as provide an overview of the treatment of LCH in the developing world. Thus, this book will not only provide the reader with a comprehensive overview of childhood LCH but will also provide the most recent up to date evidence-based management of this rare disease.

Publishing process

Book initiated and editor appointed

Date completed: June 16th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: September 5th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: November 24th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: January 23rd 2021

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Sneha Tandon

University Hospital Southampton NHS Foundation Trust

Dr. Tandon is a locum consultant in pediatric hematology/oncology at University Hospital Southampton, UK. Her clinical interests include LCH and rare histiocytosis, acute and chronic Leukemia, and lymphomas as well as late effects of cancer therapy and survivorship. Her research interests include LCH, tumor immunology and biology; nutrition in pediatric cancer as well as drug development. Dr. Tandon has been the co-investigator for multi-center studies for CML, CNS lymphoma and nutritional intervention in children undergoing cancer chemotherapy, as well as been a co-investigator for various institutional studies including LCH, infant leukaemia, PTLD, and congenital AML. Dr. Tandon has various publications to her credit including book chapters as peer-reviewed articles.

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Introducing your Author Service Manager

Ms. Jasna Bozic

As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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