About the book
This book will aim to provide a comprehensive overview of childhood LCH. It will cover the epidemiology, clinical features, and prognostic factors. The chapters on molecular genetics and the recent advances in pathogenesis will outline the various gene mutations and molecular pathways involved in LCH pathogenesis. Newer biomarkers are being developed both for diagnosis /prognosis and disease monitoring in LCH and will be discussed in one of the chapters. The book will also provide a comprehensive review of the treatment strategies, both in the frontline as well as relapse/reactivation settings. Additional aspects covered will include the endocrine complications, CNS neurodegeneration and late effects of LCH therapy. Lastly, the book will also provide an overview of the recent advances in the treatment of LCH including recent and current trials, as well as targeted therapy as well as provide an overview of the treatment of LCH in the developing world. Thus, this book will not only provide the reader with a comprehensive overview of childhood LCH but will also provide the most recent up to date evidence-based management of this rare disease.