Open access peer-reviewed Edited Volume

Collagen Biomaterial

Nirmal Mazumder

Manipal School of Life Sciences, Manipal Academy of Higher Education

A researcher with more than 10 years of experience in the fields of biophysics, biophotonics, photonics, physics, and bioinformatics. Dr. Mazumder has previously worked at the National Yang-Ming University in Taiwan, the University of Virginia, USA, and the Italian Institute of Technology in Genoa. He is a member of several national and international scientific societies including the Optical Society (OSA), Society of Biological Chemists, and the Environmental Mutagen Society of India.


Sanjiban Chakrabarty

Manipal School of Life Sciences

A researcher in the field of cancer biology, 3D tumor model, microfluidics, tumor evolution, and mitochondrial biology. Dr. Chakrabarty has spent his postdoctoral training at Erasmus Medical Center, The Netherlands. During his research, he has identified a set of methylation signatures that correlates with disease progression, HR status, and menopausal status in a breast cancer cohort in collaboration with Philips Research India for which he has become a holder of a patent.


Extracellular Matrix Tumor Growth Tissue Regeneration Cross-Linking Biomaterials Second Harmonic Generation Microscopy Imaging Wound Healing Drug Delivery 3D Bioprinting Microstructural Characterization

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About the book

In this book, we will discuss the recent developments in collagen biomaterials in tissue engineering, imaging, and their technological advancements. Advanced imaging techniques have widespread applications by providing a more comprehensive understanding of the pathomechanism of collagen disorders, which is quite useful in the early diagnosis of the pathological and physiological changes associated with various diseases. Chapters on collagen for drug delivery systems will also be highlighted for understanding pathological diseases. Chapters on advanced optical microscopy techniques, including optical coherence tomography (OCT), miniscope, multiphoton fluorescence (2PF & 3PF), adaptive optics, harmonic generation, and Raman microscopy are discussed. Also, the potentials and challenges for future researches in exploring possible applications will be discussed. It will be of great value to both students and researchers working in the field of development or applications of collagen biomaterials to understand the structure and biochemical pathways of collagen. Although several books have dealt with various aspects of collagen mechanism and the biology of the collagen, to our knowledge, no volume exists that summarizes advanced tools including optical and non-optical in collagen biomaterials. Our overall goal is to collect a series of review chapters, which would cover most of the key applications of collagen biomaterials in understanding the normal and abnormal states of the tissue.

Publishing process

Book initiated and editor appointed

Date completed: September 9th 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: October 7th 2021

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: December 6th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: February 24th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: April 25th 2022

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About the editor

Nirmal Mazumder

Manipal School of Life Sciences, Manipal Academy of Higher Education

Dr. Nirmal Mazumder is an Assistant Professor at Department of Biophysics, Manipal School of Life Sciences, Manipal Academy of Higher Education (MAHE), Manipal, India. He obtained his Ph.D. degree in 2013 with work on development of multimodal nonlinear optical microscopy for cell to tissue characterization from National Yang-Ming University, Taipei, Taiwan. After that, he worked in the University of Virginia, USA and Italian Institute of Technology, Genoa, Italy as a postdoctoral fellow during 2013 to 2016. He has been working in the area of development of nonlinear optical microscopes including two photon fluorescence, second harmonic generation (SHG), coherent anti-Stokes Raman scattering (CARS) for biomedical applications. He has demonstrated that using CARS microscopy, the expression of domain 2 of the HCV core protein (D2) fused to a GFP is sufficient to induce an accumulation of larger lipid droplets in the perinuclear region. Additionally, fluorescence lifetime imaging of endogenous reduced nicotinamide adenine dinucleotides [NAD(P)H], are performed, a key coenzyme in cellular metabolic processes, to monitor changes in the cofactor’s abundance and conformational state in D2-GFP transfected cells. He developed a four-channel photon counting based Stokes-polarimeter for spatial characterization of polarization effects in SHG signal and report on measurements and characterization of polarization properties of SH signals. The technique is used as contrast mechanism to characterize the polarization properties from two potassium dihydrogen phosphate (KDP) micro-crystals, collagen type-I and starch granules in SHG microscopy. This technique can be applied to investigate the molecular orientation and the degree of organization in fibrotic collagen, human dermis, keloid, cornea, microtubules as well as myosin of the skeletal muscle. Currently, he is working on the development of Stokes-Mueller based polarization microscope for tissue characterization integrated with machine learning. He is also developing a two photon fluorescence lifetime imaging system for brain imaging in freely moving mouse at hypoxic condition. He has more than 10 years of teaching experience in biophysics, biophotonics, photonics, physics and bioinformatics. His research work generated more than 35 publications in peer reviewed journals and also in conference proceedings, books, book chapters and several poster/oral/invited presentations in national and international conferences. He is also the Principle Investigator in several national and international collaborative research projects funded by Government of India. He is also working as the reviewer/guest editor/associate editor/book editor in several prestigious journals and publishers. He is a member of several national and international scientific societies and organizations including the Optical Society (OSA), SPIE—the International Society for Optical Engineering, Society of Biological Chemists (I) (Life Member) and the Environmental Mutagen Society of India (Life Member).

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