About the book
The circadian rhythm plays a vital role in the regulation of physiological processes, and its disturbances can lead to numerous pathophysiological disorders. Many physiological processes show evident daily variations dependent on the circadian rhythm, i.e., physiological process alternates between day and night. Circadian rhythm is associated with multiple aspects of physical health because it has an impact on the regulation of homeostasis and physiological processes. Life should be synchronized within 24 hours to maintain physiological homeostasis and optimal functioning. However, modern society is promoting a lifestyle in which activities often take place during the body's 'biological night'. This circadian desynchronization could increase the risk of developing many disorders and diseases and also affect the treatment response. It has been shown that many diseases are closely related to circadian rhythm disorders. Clock genes variations are associated with sleep disorders, various psychiatric disorders, obesity, and metabolic disorders, cardiovascular events, infertility, and tumorigenesis. Understanding the connection between circadian clock and disease might help us to illuminate the pathogenesis of circadian-related diseases, which contributes new approaches for disease prevention and treatment. The endogenous circadian rhythm has a significant part in different perspectives of well-being, and there is growing evidence showing the essential parts of the circadian rhythm in the disease development risk. The circadian rhythm adjusts the physiological functions of the individual daily. In the age of personalized medicine, knowledge of an individual's circadian rhythm could be essential for treatment (chronotherapy) and could be included as a crucial component of the diagnostic process.