Open access peer-reviewed Edited Volume

Circadian Rhythm

Ivana Škrlec

University Josip Juraj Strossmayer of Osijek


Sleep-wake Rhythms Light-darkness Cycle Shift Work Jet Lag Chronotherapy Depression Melatonin Metabolism Cardiovascular Disease Reproduction Cancer Risk

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About the book

The circadian rhythm plays a vital role in the regulation of physiological processes, and its disturbances can lead to numerous pathophysiological disorders. Many physiological processes show evident daily variations dependent on the circadian rhythm, i.e., physiological process alternates between day and night. Circadian rhythm is associated with multiple aspects of physical health because it has an impact on the regulation of homeostasis and physiological processes. Life should be synchronized within 24 hours to maintain physiological homeostasis and optimal functioning. However, modern society is promoting a lifestyle in which activities often take place during the body's 'biological night'. This circadian desynchronization could increase the risk of developing many disorders and diseases and also affect the treatment response. It has been shown that many diseases are closely related to circadian rhythm disorders. Clock genes variations are associated with sleep disorders, various psychiatric disorders, obesity, and metabolic disorders, cardiovascular events, infertility, and tumorigenesis. Understanding the connection between circadian clock and disease might help us to illuminate the pathogenesis of circadian-related diseases, which contributes new approaches for disease prevention and treatment. The endogenous circadian rhythm has a significant part in different perspectives of well-being, and there is growing evidence showing the essential parts of the circadian rhythm in the disease development risk. The circadian rhythm adjusts the physiological functions of the individual daily. In the age of personalized medicine, knowledge of an individual's circadian rhythm could be essential for treatment (chronotherapy) and could be included as a crucial component of the diagnostic process.

Publishing process

Book initiated and editor appointed

Date completed: October 16th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: January 5th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 25th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 24th 2020

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Ivana Škrlec

University Josip Juraj Strossmayer of Osijek

Dr. Ivana Škrlec obtained her degree in Molecular Biology at the Faculty of Science, the University of Zagreb and her Ph.D. in Biomedicine and Health from the Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia. She obtained a degree in Molecular Diagnostics at Postgraduate Specialist Study at the Faculty of Pharmacy and Biochemistry at the University of Zagreb. Currently, she is a postdoctoral researcher and also head of the Histology, Genetics, Cellular, and Molecular Biology Laboratory at the Department of Biology and Chemistry at the Faculty of Dental Medicine and Health, University of Osijek, Croatia. Her research fields are medical genetics and molecular biology studies in cardiovascular diseases and the circadian rhythm. She actively publishes original research work and has experience as a reviewer for international journals. She serves as a member of the editorial board of the Journal of Clinical and Medical Research.

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