About the book
Severe insulin resistance and lipodystrophy syndromes represent a heterogeneous group of rare disorders characterized by marked insulin resistance, major metabolic derangements and a number of clinical manifestations and severe complications. These syndromes can be congenital or acquired, with their pathophysiology being related to defects in insulin signaling and/or alterations of adipose tissue development and function. Nevertheless, the exact molecular and cellular mechanisms underlying the development of insulin resistance and adipose tissue dysfunction are still not entirely understood for many of these syndromes. In addition, most of these syndromes are often misdiagnosed or unrecognized in clinical practice. Therefore, prompt diagnosis and personalized treatment regimens are critical to reduce the risk of severe complications and mortality associated with these conditions.
This book intends to provide the reader with a comprehensive overview of severe insulin resistance and lipodystrophy syndromes, spanning from molecular mechanisms and pathophysiology to disease diagnosis and management in clinical settings.