Open access peer-reviewed Edited Volume

Insulin Resistance and Lipodystrophy Syndromes - From Molecular Mechanisms to Treatment Strategies

Marco Infante

University of Rome Tor Vergata

Clinical Researcher (diabetes research areas), Adjunct Professor of Endocrinology at UniCamillus (Rome, Italy), Fellow of the American College of Nutrition, and member of the Diabetes Research Institute Federation (DRIF; Italy-USA).


Insulin Receptor Insulin Secretion Insulin Synthesis Impaired Glucose Tolerance Diabetes Mellitus Metabolic Abnormalities Genetic Testing Lipodystrophy Diet Physical Activity HALS Omega-3 Acids

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About the book

Severe insulin resistance and lipodystrophy syndromes represent a heterogeneous group of rare disorders characterized by marked insulin resistance, major metabolic derangements and a number of clinical manifestations and severe complications. These syndromes can be congenital or acquired, with their pathophysiology being related to defects in insulin signaling and/or alterations of adipose tissue development and function. Nevertheless, the exact molecular and cellular mechanisms underlying the development of insulin resistance and adipose tissue dysfunction are still not entirely understood for many of these syndromes. In addition, most of these syndromes are often misdiagnosed or unrecognized in clinical practice. Therefore, prompt diagnosis and personalized treatment regimens are critical to reduce the risk of severe complications and mortality associated with these conditions.

This book intends to provide the reader with a comprehensive overview of severe insulin resistance and lipodystrophy syndromes, spanning from molecular mechanisms and pathophysiology to disease diagnosis and management in clinical settings.

Publishing process

Book initiated and editor appointed

Date completed: September 15th 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: October 13th 2021

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: December 12th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 2nd 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 1st 2022

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Marco Infante

University of Rome Tor Vergata

Marco Infante (MD, FACN) serves as Adjunct Professor of Endocrinology at UniCamillus, Saint Camillus International University of Health Sciences (Rome, Italy). Starting from January 2019, Dr. Infante has been serving as a Research Scholar at Diabetes Research Institute (DRI) of the University of Miami Miller School of Medicine (Miami, FL, USA). He is currently carrying out clinical and research activities in the field of endocrinology, diabetes and metabolic disorders at the Department of Systems Medicine of University of Rome Tor Vergata (Rome, Italy). He is a member of several international scientific organizations, including Diabetes Research Institute Federation (DRIF), American Diabetes Association (ADA) and International Pancreas and Islet Transplant Association (IPITA). Dr. Infante serves on the Editorial Board of several international peer-reviewed journals, including Frontiers in Endocrinology, Frontiers in Clinical Diabetes and Healthcare, Frontiers in Public Health, and Frontiers in Immunology. Starting from January 2020, Dr. Infante has been serving as the Managing Editor of CellR4, an open access, peer-reviewed, multidisciplinary international journal with a scope ranging from fundamental new discoveries in basic science to translational, clinical trials and delivery of novel therapeutic options. In May 2020, Dr. Infante has been appointed Supervisor for the international Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA) of the Universal Scientific Education and Research Network. Starting from April 2021, Dr. Infante has been holding the designation of Fellow of the American College of Nutrition (FACN) by virtue of his research in the field of immunomodulatory nutrition.

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