Open access peer-reviewed Edited Volume

From Pathophysiology to Treatment of Huntington's Disease

Natalia Szejko

Medical University of Warsaw

A neurologist with extensive research and clinical experience in movement disorders, especially tics and Tourette syndrome. Dr. Sezjko is Secretary of the European Society for the Study of Tourette syndrome, co-author of the new European Guidelines for the assessment and treatment of Tourette syndrome. She is also finalizing her residency in Neurology at the Medical University of Warsaw. Dr. Szejko has been working as a Postdoctoral Associate in the Department of Neurology, Yale University, USA.


Huntington's Disease Chorea Pathogenesis Neuroimaging Clinical Phenotype Motor Disturbances Cognitive Changes Neuropsychiatric Biomarkers Neuroimaging Biomarkers Biofluid Biomarkers Clinical Trials

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About the book

Huntington's disease (HD) is a progressive neurodegenerative disease of the inherited origin characterized both by psychiatric and motor symptoms. The main pathophysiological mechanism behind this is an accumulation of mutant huntingtin in the brain which leads to neuronal dysfunction and death. A number of other molecular mechanisms such as neurotoxicity, metabolic changes, and abnormal protein aggregation have also impacted the occurrence of HD. In recent years important transnational and transcontinental studies such as Enroll-HD enabled the accumulation of clinical, biofluid, and genetic data in large cohorts of HD patients. This, in turn, facilitates novel discoveries both related to the pathophysiology and treatment of HD. Researchers are mainly focused on the efforts to unravel potential biomarkers of disease progression and, first and foremost, find new therapy avenues.

The scope of this book will give an overview of the current state of the art as well as future directions regarding etiology, pathogenesis, diagnosis, and clinical variability and treatment of Huntington's Disease.

Publishing process

Book initiated and editor appointed

Date completed: September 9th 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: October 7th 2021

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: December 6th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: February 24th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: April 25th 2022

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Natalia Szejko

Medical University of Warsaw

Natalia Szejko (MD, PhD) graduated from Medical University of Warsaw in 2014 and obtained the degree of Medical Doctor. She also studied parallelly the culture of Spain and Latin America, particularly literature and theatre of this region and obtained the degree of bachellor in 2010, MA in 2012 and PhD in 2018 (Department of Neophilology, University of Warsaw). In 2020, she has also defended ScD dedicated to clinical phenomenology of tics in Gilles de la Tourette Syndrome in 2020 (Department of. Neurology of Medical University of Warsaw). She is also finalizing her residency in Neurology in Department of Neurology of Medical University of Warsaw. Between 01.01-31.12.2020 she has been working as Postdoctoral Associate in Department of Neurology, Yale University, USA. From 2016 she is working as Assistant Professor in the Department of Bioethics in Medical University of Warsaw and is conducting interdisciplinary studies dedicated to medicine, literature, cinema and theatre. From clinical perspective she is also interested in tics, movement disorders and overlap between Neurology and Psychiatry. She has been awarded several prizes such as Rojszczak Award, scientific prize of "Polityka" in 2019 and was nominated as "Personality of 2019" for the journal Polska Times. She has also been awarded several fellowships and established international collaboration: Erasmus Fellowship for PhD students in Clinic of Psychiatry, Socialpsychiatry of Hannover Medical School, Germany, clinical fellowship of Movement Disorders Society and European Huntington's Disease Network, Department of Neurology, Ramon y Cajal Hospital, Madrid, Spain; clinical fellowship of European Academy of Neurology, Department of Neurology, Medical University of Innsbruck, Austria; research fellowship awarded by the Kosciuszko Foundation in the Child Study Center, Yale University, USA. She is author of 30 medical publications, 7 chapters in books and 20 publications dedicated to the overlap between medicine and humanities. She is the first author (part dedicated to assessment and deep brain stimulation) of the new European Society for the Study of Tourette Syndrome which will be released in 2020. In 2020 she has been elected as a Board Member and Secretary of the European Society for the Study of Tourette Syndrome.

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