About the book
Huntington's disease (HD) is a progressive neurodegenerative disease of the inherited origin characterized both by psychiatric and motor symptoms. The main pathophysiological mechanism behind this is an accumulation of mutant huntingtin in the brain which leads to neuronal dysfunction and death. A number of other molecular mechanisms such as neurotoxicity, metabolic changes, and abnormal protein aggregation have also impacted the occurrence of HD. In recent years important transnational and transcontinental studies such as Enroll-HD enabled the accumulation of clinical, biofluid, and genetic data in large cohorts of HD patients. This, in turn, facilitates novel discoveries both related to the pathophysiology and treatment of HD. Researchers are mainly focused on the efforts to unravel potential biomarkers of disease progression and, first and foremost, find new therapy avenues.
The scope of this book will give an overview of the current state of the art as well as future directions regarding etiology, pathogenesis, diagnosis, and clinical variability and treatment of Huntington's Disease.