Open access peer-reviewed Edited Volume

The Metabolism and Biological Activity of Unsaturated Fatty Acids in Health and Disease

Daniel Guerra

VerEvMed LLC


natural occurrence dietary trans fatty acids biosynthesis membrane fluidity and structure sphingolipid signaling cerebrosides and gangliosides protein transport hormonal signaling organelle turnover and replication protein acylation immune response epigenetics

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About the book

The introduction of double bonds into long chain fatty acids (desaturation) is essential for human health and reproduction. These unsaturated fatty acids play key roles in the immune response and normal cellular processes including membrane structural and functional dynamics, intra- and extra-cellular signaling, and subcellular organization and turnover, including autophagic and apoptotic phenomena. Polyunsaturated fatty acids are necessary for membrane fluidity maintenance and voltage gated ionic transport thus supporting and maintaining polarity and excitation as in neural synaptic action potentials. Essential fatty acid desaturation and elongation are required for glycero- and sphingo-lipid biosynthesis and functional complexity in all aspects of normal physiological states and when corrupted, can be central to devastating cardiovascular and metabolic diseases and cancer. Complementary and alternative medicines often include pre-formed polyunsaturated positional and geometric isomers of fatty acids that have not been thoroughly vetted in human health and longevity thus requiring a careful examination of their wide-scale use. Trans fatty acids have been implicated in human disease but careful examination of the literature does not consistently support this perspective since these positional isomers are common in metabolism and essential complex lipid occur in the central and peripheral nervous systems. Human health and disease are necessarily linked to unsaturated fatty acids.

Publishing process

Book initiated and editor appointed

Date completed: August 27th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: November 16th 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: February 4th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: April 4th 2020

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About the editor

Daniel Guerra

VerEvMed LLC

NAME: Daniel J. Guerra, Ph.D., Co-Founder and Chief Scientific Officer of VerEvMed ( DEGREES EARNED: PhD 1984: Biochemistry and Physiology-Plant Science, Utah State University; MS 1981: Plant Biochemistry, University of Arkansas; BS 1978: Agriculture, Agronomy, University of Illinois. Dr. Guerra has been a university professor of biochemistry and molecular genetics for 3 decades. He has also been an active research scientist working primarily on lipid metabolism and neuroscience with strong interests in gene expression, epigenetics and immunology. Currently Dr. Guerra is the co-founder and CSO of VerEvMed, a biomedical consultancy company that specializes in the examination and verification of the published research literature for the purpose of making this information available to a wider audience of health professionals, institutions, students, and interested lay people.

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