Open access peer-reviewed Edited Volume

Sleep Medicine and the Evolution of Contemporary Sleep Pharmacotherapy

Denis Larrivee

Loyola University Chicago

Dr. Larrivee has held professorships at the Weill Cornell University Medical College and Purdue University, Indiana. He is a former fellow of Yale School of Medicine, a leading researcher in global brain communication, IEEE BRAIN national consultant, International Neuroethics Society Expert, and chief editor of 4 texts on topics of Brain-Computer Interfacing, Neurostimulation, and Alzheimer's Disease. He is the author of more than 90 papers.


Circadian Rhythms Insomnia Disorder Hypersomnia Narcolepsy Hypnosedative Benzodiazepines Orexin System Blockers Melatonin Derivative Psychomotor Impairment Anterograde Amnesia Memory Consolidation Gamma Band Stimulation

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About the book

Nearly 30–40% of all adults suffers from mild to severe insomnia, with its sequels, including fatigue reduced alertness, irritability, and impaired concentration all having a major negative impact on quality of life. Growing evidence, moreover, links disturbances of sleep to substance abuse and its spectrum of mental and physical health problems, while substance use in turn has been shown to disturb circadian rhythms affecting sleep mechanisms. Sleep and sleep disturbances, in fact, significantly influence neuronal activity in midbrain DA structures suggesting that changes in neuronal activity underlie the well-known relationship between sleep alterations and several disorders such as addiction and depression. The complex interdependence of these and other brain systems with neurological activation and neurotransmitter release presents a complex picture for the therapeutic administration of sleep medications, one that has stimulated the evolution of multiple sleep medication classes each with unique efficacies and contraindications. Benzodiazepines, for example, exert sedative actions through the activation of BZ1 and BZ2 receptor subtypes of the c-aminobutyric acid (GABA)A complex, but also exert significant adverse effects like cognitive and psychomotor impairment and anterograde amnesia.

The progressive evolution in sleep medicines and the wealth of information obtained on their associated complex brain activity and neurotransmitter mechanisms indicates the exceptional productivity of current research in the field. Its promise of new therapeutic avenues for sleep disturbances and their ancillary influence on substance abuse will be covered in this up to date text about an international health issue.

Publishing process

Book initiated and editor appointed

Date completed: April 20th 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: May 18th 2021

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: July 17th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: October 5th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: December 4th 2021

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Denis Larrivee

Loyola University Chicago

Dr. Denis Larrivee is a visiting scholar at the Mind and Brain Institute, University of Navarra Medical School and Loyola University, Chicago. He has held professorships at the Weill Cornell University Medical College, NYC, and Purdue University, Indiana. A former fellow at Yale University's Medical School, Dr. Larrivee received the Association for Research in Vision and Ophthalmology's first place award for studies on photoreceptor degenerative and developmental mechanisms. He is the editor of a text on Brain Computer Interfacing and an editorial board member of the Annals of Neurology and Neurological Sciences (USA) and EC Neurology (UK). He is also the author of more than ninety-five papers and book chapters in such varied journals/venues as Neurology and Neurological Sciences, Journal of Neuroscience, Frontiers Human Neuroscience, Journal of Religion and Mental Health, and IEEE Xplore. In 2018, he was a finalist for the international Joseph Ratzinger Expanded Reason award sponsored by the Francis Vittorio University of Madrid.

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