Open access peer-reviewed Edited Volume

Ion Channels - From Basic Properties to Medical Treatment

Zuzana Sevcikova Tomaskova

Slovak Academy of Sciences

Dr. Sevcikova Tomaskova received her Ph.D. degree in biophysics from Pavol Jozef Safarik University, Slovakia. She is a senior researcher, focused on the study of mitochondrial chloride channels, using electrophysiological methods for ion channel current measurement and complex analysis.

Covering

Structure Selectivity Kinetics Voltage Sensor Mutations Behind Diseases Drug Development Molecular Mechanism Gene Therapy Cooperative Binding Phosphorylation Binding Sites Protein-Protein Interaction

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About the book

Ion channels are membrane proteins that allow the passage of ions or charged small molecules through lipid membranes. They are present in every cell of every organism. Ion channels are involved in action potential propagation, cell volume regulation, signal transduction or they act as mechanosensors. Many types of ion channels have been observed, measured, and described since their discovery. Certain ion channels are so selective that they can distinguish between two small ions such as Na+ and K+. They differ in the speed of transport, in the shape of conductive pore or gating kinetics. Last, but not least, the regulation of ion channel activity covers a broad range of mechanisms. Though the channels vary in many ways, their primary role is the same – a controlled passage of ions in a safe way not to disturb the cellular homeostasis. Ion channels, regardless of the ion type they conduct, are often the target of medical treatment (verapamil, glibenclamide, benzodiazepine, etc.). Mutations in ion channels, which affect the channel activity or permeability, are behind diseases such as cystic fibrosis, catecholaminergic polymorphic ventricular tachycardia, malignant hyperthermia, epilepsy or several other channelopathies. Ion channels are of imminent interest in the field of life sciences with possible therapeutic outcomes. Each piece of knowledge, that can help us understand their role and function, is worthy of notice.

This book provides a versicolor insight on the diversity of ion channels and their function, regulation or biophysical properties.
 

Publishing process

Book initiated and editor appointed

Date completed: September 21st 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: December 18th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 8th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 7th 2022

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About the editor

Zuzana Sevcikova Tomaskova

Slovak Academy of Sciences

Zuzana Sevcikova Tomaskova graduated in biophysics on Commenius University, Bratislava, Slovakia. In 2009, she achieved her Ph.D. degree in biophysics on Faculty of Science, Pavol Jozef Safarik University in Kosice, Slovakia. She is specialized in single channel current measurement on bilayer lipid membrane and also in advanced current analysis. She gained 2nd place in Competition of young scientists in natural sciences in 2009 and year later, she was awarded by the Award of the president of Slovak Republic for young scientists. In 2012, she received a short-term FEBS fellowship and learned single channel patch-clamp method at Nencki Institute in Warsaw, Poland. Her work is mainly focused on cardiac mitochodrial chloride channels. Currently, she is senior reseracher at Centre of Biosciences, Slovak Academy of Sciences.

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