About the book
Once considered, as a seat of the soul by Babylonians, liver plays a puissant role in the metabolism of not only food but also various drugs and toxins. Although far-fetched from the thought of Hepatomancy, its unique anatomic location canoodling the GI tract and systemic circulation, it is a major organ for detoxification. It serves a multitude of functions that include synthetic, digestive and metabolic role, which cannot be simply replicated even in the sophisticated settings. Thus it appears prudent to preserve its integrity pending an irrevocable state induced by menacing insult. Any insults, be it traumatic, or circulatory dysfunction portends a poor prognosis if there is liver involvement. Understanding pathogenesis could envisage future therapies that might salvage or conceivably even completely shield the liver from the injury. Given its multifarious abilities, there is a myriad clinical sequela that can follow liver injury, the goals of therapies of which differ. This book describes the molecular pathogenesis and pathobiology of liver failure and presents an exhaustive discussion of evidence-based practices for supportive management including extracorporeal therapies. Although current treatments are far from every hepatologist dream of having an incredible power of regeneration as described in Prometheus of Greek mythology, it inevitably sets as a benchmark for further research.