About the book
Toxicity testing is a significant part of the process of evaluation of the hazards and risks that different xenobiotics present to humans, animals or the environment. The cytotoxic response plays a major role in determining the potential toxicity of any xenobiotic, including e.g., nanoparticles, pesticides, biomolecules, medical devices, drugs and radiation, towards living organisms. The identification of cytotoxic properties may be crucial in helping to explain target cells and organ toxicity. There are many different as well as highly recommended types of bioassay for estimating the cellular response and the presence of dead cells. The selection of suitable cytotoxicity bioassays is crucial for the accurate assessment of xenobiotic toxicity, and more than one methodology may be required to understand the complete toxicity profile due to numerous sublethal cellular changes that may occur after a short period of exposure.
The book “Cytotoxicity” aims to present the rationale, strategies, methods, interpretations and recent advances in the in vitro toxicity, presenting both theoretical and practical aspects.