Open access peer-reviewed Edited Volume

Applications of RNA-Seq in Biology and Medicine

Irina Vlasova-St. Louis

University of Minnesota

Dr. St. Louis conducts discovery research in several key areas including infectious diseases, immunology, and oncology. By integrating specific areas of expertise - genomics, transcriptomics, proteomics, ribonomics, and bioinformatics - Irina’s group is studying normal and pathological conditions at the molecular, cellular, and organismal levels.

Covering

RNA-Seq Genomics Transcriptomics Gene Expression Transcriptome Profiling Genetic Variation Single-Cell Genomics Single-Cell Genome Data Mining Bioinformatics Transcriptomic Biomarkers Inherited and Somatic Diseases

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About the book

The advent of next-generation sequencing along with the development of bioinformatics tools has opened avenues to explore this technology in numerous fields of biomedical research. This book evaluates and comprehensively summarizes the scientific findings which have been achieved through RNA-Seq technology. RNA-Seq allows us to accurately capture all subtypes of RNA molecules, in any sequenced organism or single-cell type, under different experimental conditions. RNA-Seq transcriptome profiling of healthy and diseased tissues allows understanding the alterations in cellular phenotypes through the expression of differentially spliced RNA isoforms. Assessment of gene expression by RNA-Seq provides new insight into host response to pathogens, drugs, allergens, and other environmental triggers.

RNA-sequencing becomes even more powerful when combined with other assays. Merging genomics and transcriptomic profiling provides novel information underlying causative DNA mutations and the cellular effects of genetic variants caused by SNPs, indels, etc. Combining RNA-Seq with immunoprecipitation and cross-linking techniques is a clever multi-Omics strategy assessing transcriptional, posttranscriptional and posttranslational levels of gene expression regulation. The optimization of RNA-Seq technology will allow countless opportunities in our pursuit of achieving the goals of individualized medicine.

Publishing process

Book initiated and editor appointed

Date completed: August 19th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: November 8th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: January 27th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: March 28th 2021

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About the editor

Irina Vlasova-St. Louis

University of Minnesota

Irina St. Louis earned her M.D. and Ph.D. degrees from Ural State Medical Academy, Yekaterinburg, Russia. She completed her residency in lab pathology at Russian Medical Academy for Postgraduate Education, Moscow. She joined the Department of Microbiology at the University of Minnesota, as a postdoctoral trainee, followed by fellowships at the University of Minnesota Supercomputing Institute and Lymphoma Research Foundation. Presently, Dr. St. Louis is appointed as an Assistant Professor at the Department of Medicine at the University of Minnesota. Dr. St. Louis conducts discovery research in several key areas including infectious diseases, immunology, and oncology. By integrating specific areas of expertise - genomics, transcriptomics, proteomics, ribonomics, and bioinformatics - Irina’s group is studying normal and pathological conditions at the molecular, cellular, and organismal levels. The basic research in Dr. St. Louis’ laboratory is centered on post-transcriptional gene expression regulation, specifically, through messenger RNA turnover. Her translational research focuses on immune restoration disorders (IRD). Dr. St. Louis is engaged in a number of clinical studies, within the Global Health & International Medicine Program. These studies involve the stratification of AIDS patients, for optimal treatment regimens. The studies also include searches for biomarkers of immune reconstitution inflammatory syndrome (IRIS). Additionally, Dr. St. Louis’ lab collaborates with the Division of Hematology-Oncology and Transplantation, on virus-specific immune reconstitution after various hematopoietic cell transplantation regimens. This collaborative research aims to define the parameters and conditions for favorable post-transplant immune restoration and functional recovery in adult patients.

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