About the book
In this book, our goal is to start a discussion on various forms of cardiomyopathy, including ischemic, idiopathic, infectious, alcoholic, toxic, viral, hypertrophic, obstructive, peripartum, and postpartum. We will also discuss the etiology, the genetic pathophysiology, the diagnosis, the significance of biomarkers, the effect on multiple organs, and the management options available along with recent advances. Cellular dysfunction happens at the molecular level if the patient has underlying risk factors like diabetes versus nondiabetic patients. In diabetes, patients have hyperglycemia glucotoxicity, which can lead to oxidative stress and mitochondrial dysfunction leading to impaired autophagy ad abnormal calcium handling. The insulin resistance can also explain the activation of inflammatory markers and RAAS overactivation, in turn leading to endothelial dysfunction and substrate shift towards increased free fatty acids oxidation. We also hope to discuss cardiac imaging advances in the diagnosis of various forms of cardiomyopathy and their unique morphological patterns. Life expectancy will also be tackled as well as interventional approaches to cardiomyopathy treatment. We hope this book will bring discussions on lifestyle changes and personal challenges, including mental health, hospice, palliative care options, and family support options.
