Open access peer-reviewed Edited Volume

Cytokeratins

Miroslav Blumenberg

New York University Langone Medical Center

Dr. Blumenberg pioneered the use of DNA microarrays in skin biology. His H-index of 35 is a clear indicator of his merit and impact as a researcher. He serves on editorial boards of BMC Genomics, Acta Dermatovenerologica APA, and World Journal of Biological Chemistry and holds three patents.

Covering

Cytoplasm Cytokeratin-associated Proteins Signal Transduction Actin Tubulin Integrins Extracellular Matrix Disruptions and Diseases Promoters Transcription Factors Tissue Specificity Keratinopathies

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About the book

Cytokeratins are the most diverse and, arguably least understood components of the cytoskeleton. Comprising the intermediate filaments of epithelial cells, cytokeratins have roles in tissue integrity, in signaling, attachment to a substrate, and providing scaffolding to cytoplasmic organelles including, presumably, the nucleus. Essentially insoluble filamentous structures, these assemblies disappear during mitosis, to re-assemble immediately afterward. Beyond the confines of epithelial cells, keratins provide the bulk material to the epidermal stratum corneum, hair, nails and other rigid elements of the integument. Cytokeratins are obligate heteropolymers, consisting of equal amounts of Type I, acidic, and Type II neutral to basic proteins. In mammals, the Type I keratin genes are clustered in a single chromosomal region, and so are the Type II keratin genes. Different cytokeratins are characteristic molecular marker for specific epithelia, e.g., epidermis, cornea, tongue, hair etc. Mutations in keratin genes have dominant inheritance, in accordance with their obligate polymerization, and can cause severe disorders. Lately, first successes in correcting the mutant phenotype have been achieved using DNA-targeted therapies. Recent progress in studies of these fascinating proteins warrants a recap at this moment, which this volume aims to provide.

Publishing process

Book initiated and editor appointed

Date completed: September 8th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: October 6th 2020

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Approved chapters written in full and submitted

Deadline for full chapters: December 5th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: February 23rd 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: April 24th 2021

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About the editor

Miroslav Blumenberg

New York University Langone Medical Center

Miroslav Blumenberg, PhD, was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his PhD at MIT in Organic Chemistry; he followed up his PhD with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is a codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on skin. He has published more than 100 peer-reviewed research articles and graduated numerous PhD and postdoctoral students. Dr. Blumenberg lives in New York, USA, with his wife and two children.

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Book chapters authored 5

Books edited 6

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