Open access peer-reviewed Edited Volume

Narcolepsy

Murat Kayabekir

Atatürk University

Covering

HLA types Hypocretin System Orexin Deficiency REM Sleep Familial Aspects HLA-peptide HLA DQB1*0602 Twin Studies Sleepiness Cataplexy Sleep Paralysis Hallucinations Epworth Sleepiness Scale SOREMPs MSLT CSF Hypocretin (Orexin) Behavioral Approaches Pharmacologic Children Medication Side Effects

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About the book

REM behaviour has a special role in human sleep physiology. Rapid eye movements, dreams, skeletal muscle atonia, and autonomous-sympathetic nervous system questions the brain and its importance, and what it really means again and again with EEG signals. Therefore repeating REM waves in the brain, REM physiology and pathophysiology should be studied more in depth. We can regard narcolepsy as a type of REM physiology abnormality due to two important conditions: sleep paralysis, and dreaming phenomenon. A narcoleptic patient experiences both conditions while asleep or waking up from sleep during REM. Narcolepsy can be conceptualized as blurring of the borders of the brain while awake, sleeping or dreaming. An awake narcoleptic can feel as if sleepy and can even see dreams. In the classical sense, narcolepsy is characterized by hypersomnolence during the day associated with REM sleep phenomenon and cataplexy encompassing sleep paralysis and hypnogogic hallucinations. The fundamental pathophysiology of narcolepsy is related to a deficiency of hypocretine (orexine) which is an important component of the hypothalamic neuropeptide system.
Historically the word narcolepsy was first used by Ge´lineau in 1880 to describe irresistible episodes of sleep that were repetitive with short intervals. In 1950s Kleitman was the first individual to discover REM. Since then, laboratories that can record electrophysiological signals have been developed and possibilities for diagnosing, treating and monitoring sleep disorders have increased. However, narcolepsy can still be mixed with sleep disorders and neuropsychiatric disorders.
This book aims at tackling narcolepsy from both basic science and clinical science perspectives. The reader will be able to grasp physiological mechanisms on one hand while associating narcolepsy with clinical diseases on the other. In narcolepsy there are disrupted night-day and sleep-wakefulness rhythms. Once this rhythm is hindered, the individual is confronted with biological, psychological and social problems. Narcoleptics are faced with the risk of collapsing and being knocked down to the floor while in kitchen or at the park, when driving in the traffic or walking down the stairs at any given moment.

This book will not only provide a resource for physicians who will be helping this group of patients, but will at the same time contribute to the pathophysiology of the disease as it contains up to date information for researchers focusing on innovations in this field.

Publishing process

Book initiated and editor appointed

Date completed: November 13th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: February 2nd 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: April 22nd 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: June 21st 2020

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Murat Kayabekir

Atatürk University

Murat Kayabekir is an Associate Professor in the Department of Physiology at Atatürk University Medical School. He has completed Physiology training at Hacettepe University Medical School. He worked as a physiology specialist at the Sleep Disorders Centers and Electrophysiology Laboratory as a founder and director. His scientific fields of study are: neurophysiology, electrophysiology, sleep physiology and disorders, PSG and computer engineering, snoring sound analysis, sleep EEG and sleep spindles, innovative products, REM behavior disorders, narcolepsy, sleep apnea, bruxism, insomnia, and epilepsy during sleep.

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As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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