Open access peer-reviewed Edited Volume

Epigenetics - “A Parallel Universe” in the Study of Cancer Biology

Mumtaz Anwar

University of Illinois at Chicago

Dr. Anwar is a member of various scientific organizations and societies including American Heart Association (AHA), American Society for Pharmacology and Experimental Therapeutics (ASPET), ASPET Young Scientists Committee, North American Vascular Biology Organization (NAVBO), United States and Canadian Academy of Pathology (USCAP).

Co-editors:

Zeenat Farooq

Government Medical Srinagar

Dr. Zeenat is the author of a book and journal articles about epigenetics and chromatin remodeling and is involved in other scientific activities. She is the recipient of various awards and honors including CSIR-UGC, ASRB-NET, GATE, Merit scholarship, RA ship from ICMR.

Riyaz Ahmad Rather

Wachemo University

Mohammad Tauseef, Ph.D., is currently an Assistant Professor at the Department of Pharmaceutical Sciences, College of Pharmacy, Chicago State University, Illinois, USA. He is the recipient of various awards including AHA Postdoctoral fellowship, Midwest Affiliate, Outstanding Young Investigator Travel Award, Research Recognition award, Best Teacher award, and other Postdoctoral competition category awards.

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Mohammad Tauseef

Chicago State University

Mohammad Tauseef, Ph.D., is currently an Assistant Professor at the Department of Pharmaceutical Sciences, College of Pharmacy, Chicago State University, Illinois, USA. He is the recipient of various awards including AHA Postdoctoral fellowship, Midwest Affiliate, Outstanding Young Investigator Travel Award, Research Recognition award, Best Teacher award, and other Postdoctoral competition category awards.

Covering

Gene Expression Post-translational Modification Chromatin Non-coding RNAs Classification Functioning Human Diseases Epigenetic Dysregulation Cancer DNA Methylation Histone Methylation Histone Acetylation

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About the book

Efforts to curb human diseases have always been at the heart of modern medicine and research. Among these diseases, cancer occupies a central position primarily due to high cost of management and high rates of mortality. Over the last two decades, a plethora of research has focused on understanding the molecular basis of cancer development. Various aspects of this debilitating disease have been uncovered including dysregulation and signaling pathways, evasion of immune responses and so on. However, this only represents a “drop in a notion” and thus a lot of research-based evidence is still required to fully understand and thereby curb the debilitating disease. As Epigenetics, represents the non-nucleotide based hereditary changes in the genome, has recently emerged as an interesting field in the studies of cellular mechanisms in normal and disease states. Among the key regulators of epigenetics, histone post-translational modification, non-coding RNAs and chromatin remodelers have been shown to play a significant role in governing various aspects of cancer.

Epigenetic events have also been shown to impact cancer development through cooperation of genomic elements. The discovery of cancer related mutation in the regulatory genome elements that directly affect the epigenome is an area of immense interest. The impact of epigenetic changes on cancer onset and progression has become increasingly evident and this particular field has seen tremendous progress over the last few years with the advent of state of the art technology through the utilization of various techniques including next generation sequencing of non-coding RNAs and immunoprecipitated chromatin, methylome/transcriptome/exome sequencing, and microarrays in normal and cancerous state, our understanding of the field has tremendously increased. This has also presented us with opportunity of therapeutic intervention at epigenetic levels.

This book would focus on the role of various epigenetic mechanisms in governing cancer onset and progression. It would also encompass through the recent advances made in the field of epigenetics and their role in improving our knowledge of cancer biology.

Publishing process

Book initiated and editor appointed

Date completed: July 14th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: October 3rd 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: December 22nd 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: February 20th 2021

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Mumtaz Anwar

University of Illinois at Chicago

Mumtaz Anwar, PhD, is currently a Postdoctoral Research Scientist at the Department of Pharmacology and Regenerative Medicine, College of Medicine, University of Illinois at Chicago, Illinois, USA. Dr Anwar obtained his PhD in Cancer Biology and Molecular Epigenetics at the Faculty of Medicine, department of Gastroenterology and department of Experimental Medicine and Biotechnology, PGIMER, Chandigarh, India. His PhD thesis concerned the investigation of Wnt signaling pathway in search for new tumor prognostic and biomarkers in colorectal cancer. Dr Anwar is the author of many book chapters and journal articles about tumor markers and is involved in other scientific activities in this advanced molecular technology era. He is a member of Various Scientific Organizations and societies including American Heart Association (AHA), American Society for Pharmacology and Experimental Therapeutics (ASPET), ASPET Young Scientists Committee, North American Vascular Biology Organization (NAVBO), United States and Canadian Academy of Pathology (USCAP). He is the recipient of various awards including Outstanding Young Investigator Travel Award and other Postdoctoral competition category awards. He is also an editorial board member and reviewer to review research articles to various scientific journals.

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