About the book
Efforts to curb human diseases have always been at the heart of modern medicine and research. Among these diseases, cancer occupies a central position primarily due to high cost of management and high rates of mortality. Over the last two decades, a plethora of research has focused on understanding the molecular basis of cancer development. Various aspects of this debilitating disease have been uncovered including dysregulation and signaling pathways, evasion of immune responses and so on. However, this only represents a “drop in a notion” and thus a lot of research-based evidence is still required to fully understand and thereby curb the debilitating disease. As Epigenetics, represents the non-nucleotide based hereditary changes in the genome, has recently emerged as an interesting field in the studies of cellular mechanisms in normal and disease states. Among the key regulators of epigenetics, histone post-translational modification, non-coding RNAs and chromatin remodelers have been shown to play a significant role in governing various aspects of cancer.
Epigenetic events have also been shown to impact cancer development through cooperation of genomic elements. The discovery of cancer related mutation in the regulatory genome elements that directly affect the epigenome is an area of immense interest. The impact of epigenetic changes on cancer onset and progression has become increasingly evident and this particular field has seen tremendous progress over the last few years with the advent of state of the art technology through the utilization of various techniques including next generation sequencing of non-coding RNAs and immunoprecipitated chromatin, methylome/transcriptome/exome sequencing, and microarrays in normal and cancerous state, our understanding of the field has tremendously increased. This has also presented us with opportunity of therapeutic intervention at epigenetic levels.
This book would focus on the role of various epigenetic mechanisms in governing cancer onset and progression. It would also encompass through the recent advances made in the field of epigenetics and their role in improving our knowledge of cancer biology.