Open access peer-reviewed Edited Volume

Non-Viral Vectors - Smart Materials for Gene Delivery Systems

Feray Bakan

Sabancı University


Synthetic Polymer-Based Vectors Chitosan Polysaccharides Peptides Inorganic Nanoparticles Magnetic Nanoparticles Carbon-Based Nanomaterials Lipid-Based Vectors Cationic Liposomes Lipid Nanoparticles Lipoplexes Genes

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About the book

Any mutation in the genome can cause a vast number of diseases, and the treatment of these diseases at the gene level is a very recently emerging approach in clinical practice with promising future implications. Gene therapy is described as the transfection of the therapeutic gene (DNA or RNA) either to the cytoplasm (RNA) or the nucleus (DNA) for curing various acquired and inherited diseases. This transfection can selectively improve or inhibit (antisense) gene function. As degradation of nucleic acids can occur during cellular uptake, which prevents the effective penetration of naked DNA or RNA into the cell, an appropriate carrier is needed.

There are two main sorts of carriers which are called vectors: viral or non-viral vectors. Although viral vectors exhibit higher transfection efficiencies compared to non-viral based delivery, their adverse effects such as immunogenicity, oncogenicity, and cytotoxicity may cause limitations in clinical use. To overcome these drawbacks, non-viral vectors including, but not limited to polymers, lipids, and inorganic nanoparticles have recently drawn vast attention in gene therapy. This book aims to provide the reader with a comprehensive overview of the current state-of-the-art in non-viral vectors focusing on the potential employment of several nanomaterials which can be used in gene therapy.

Publishing process

Book initiated and editor appointed

Date completed: June 16th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: September 5th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: November 24th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: January 23rd 2021

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Feray Bakan

Sabancı University

Dr. Feray Bakan received her PhD degree in chemical engineering from Ataturk University, Turkey in 2011. She was awarded with post-doctoral fellowship from the Scientific and Technological Research Council of Turkey (TUBİTAK) and worked as a post-doctoral researcher at Department of Physics, Sabancı University, Turkey from 2011 to 2013. She is currently working as a research assistant professor at Sabancı University Nanotechnology Research and Application Center (SUNUM), Turkey. Her research interests focus on bioceramic nanomaterials’ synthesis and their health-related applications ranging from bone fracture healing to drug delivery systems. As a principal investigator, Dr. Bakan conducted several national and international projects on biomedical nanomaterials and she has also participated in 3 international projects as a researcher. Recently, she is working on calcium phosphate-based nanoparticles and cyclodextrin-drug inclusion complexes. Dr. Bakan has authored or co-authored 22 SCI/Scopus indexed papers, 6 international conference proceedings, and 1 book chapter published by IntechOpen. She has delivered numerous talks in national and international conferences and is a member of the Turkish Society for Microscopy and the Materials Research Society (MRS).

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