Open access peer-reviewed Edited Volume

Antibody Engineering - Perspectives on Technology and Applications

Kalimuthu Karuppanan

University of Oxford

A cutting-edge research scientist in therapeutic protein engineering contributed to eight protein drug discoveries, holder of US patent.


Infectious Diseases Metabolic Diseases Toxicity and Immunogenicity Oral Antibodies Inhalable Antibodies Safety Regulations Hybridoma Technology B Cell Engineering In Vitro Methods Antibody-Drug Conjugates Antibody in Microbial Glycoenginee

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About the book

Antibodies are the lead molecule in diagnostic and therapeutic treatment for various infectious and metabolic diseases. Since the approval of the first antibody in 1986, at present, ~100 FDA-approved antibodies are available in the market. There are several antibodies in the clinical trials and waiting for approval. The current global market for antibody-based drugs is estimated at ~ $100 billion and is projected to be ~ $200 by 2026. Although antibody-based drugs are dominating clinical applications, there are several challenges like a high production cost, short serum half-life, toxicity, immunogenicity, and limited oral drug delivery that still need to be addressed. Next-generation antibodies have unique advantages over traditional antibodies and show great potential for current limitations. The engineering of antibodies and their production host systems enable commercial production at affordable cost and quality.

This book will aim to provide broad information about antibody engineering technologies and their application to diagnostic and therapeutics for various diseases. 

Publishing process

Book initiated and editor appointed

Date completed: February 4th 2022

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: June 6th 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: August 25th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: October 24th 2022

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About the editor

Kalimuthu Karuppanan

University of Oxford

Dr. Kalimuthu Karuppanan obtained his Ph.D. in Biotechnology from Madurai Kamaraj University, India (2013). He was a postdoctoral scientist and Lecturer in Department of Chemical Engineering, University of California, Davis, USA (2014-2018). He relocated for his second postdoctoral scientist position in Radcliffe Department of Medicine, University of Oxford, UK (2019-2021). Also, he was a Co-Investigator in Center for the Utilization of Biological Engineering in Space (CUBES) project, NASA-Space technology Research Institutes, USA, and Co-Investigator in Emergency Response to the Novel Coronavirus Pandemic (COVID-19) project funded by KFAS-Kuwait University, Kuwait. He has contributed to various therapeutic protein engineering and developments (including Zmapp cocktail antibodies for Ebola and Fc fusion proteins for SARS-CoV-2 infection). He has one approved US patent, various prestigious drug discovery awards and peer-reviewed journal publications for his research accomplishment in Biotherapeutics.

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