About the book
The center of multiomics is being moved from genomics to phenomics. Metabolomics as the important aspect of phenomics is the methodology and theory to study metabolome, including identification biochemical and molecular characteristics of metabolome, characterization of interactions among different metabolites or between metabolites and genetic/environmental factors and evaluation of biochemical mechanisms related to a given conditions such as different pathophysiological processes. Metabolome contains all metabolites derived from sugars, lipids, proteins, and nucleic acids in a given biological system, tissue, cell, or body-fluid. The metabolites in a metabolome interact mutually in enzymatic reaction systems to form metabolic network systems. The alteration in metabolome is associated with multiple factors, including genetic, environmental, internal, external, drug, or dietary factors. Currently the studies on variations in metabolome are insufficient in the width and depth in the field of metabolomics. The development of high-throughput, high-sensitivity and especially high-reproducibility approaches is necessary to maximize the coverage of variations in metabolome. The studies of metabolomic variations directly result in the discovery of effective biomarkers to clarify molecular mechanisms of a disease, determine reliable therapeutic targets, and benefit precise prediction, diagnosis, and prognosis assessment in the context of predictive, preventive and personalized (3P) medicine.
This book will focus on (i) the methodology of metabolomics, including sample preparation, targeted metabolomics, and untargeted metabolomics based on nuclear magnetic resonance (NMR) or mass spectrometry (MS), and (ii) applications of metabolomics in the research and practice of medical sciences.