Open access peer-reviewed Edited Volume


Xianquan Zhan

Shandong First Medical University

A pioneering expert in the field of proteomics and proteofroms, multiomics, biomarkers, and 3P medicine in cancer, appointed as Fellow of Royal Society of Medicine, Fellow and National Representative of EPMA, and Associate Editor of EPMA Journal and BMC Medical Genomics.


Sample Preparation Mass Spectrometry Metabolite Metabolome Nuclear Magnetic Resonance Lipid Metabolomics Targeted Metabolomics Untargeted Metabolomics Cancer Neurodegenerative Disease Endocrine Diseases Metabolic Disease

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About the book

The center of multiomics is being moved from genomics to phenomics. Metabolomics as the important aspect of phenomics is the methodology and theory to study metabolome, including identification biochemical and molecular characteristics of metabolome, characterization of interactions among different metabolites or between metabolites and genetic/environmental factors and evaluation of biochemical mechanisms related to a given conditions such as different pathophysiological processes. Metabolome contains all metabolites derived from sugars, lipids, proteins, and nucleic acids in a given biological system, tissue, cell, or body-fluid. The metabolites in a metabolome interact mutually in enzymatic reaction systems to form metabolic network systems. The alteration in metabolome is associated with multiple factors, including genetic, environmental, internal, external, drug, or dietary factors. Currently the studies on variations in metabolome are insufficient in the width and depth in the field of metabolomics. The development of high-throughput, high-sensitivity and especially high-reproducibility approaches is necessary to maximize the coverage of variations in metabolome. The studies of metabolomic variations directly result in the discovery of effective biomarkers to clarify molecular mechanisms of a disease, determine reliable therapeutic targets, and benefit precise prediction, diagnosis, and prognosis assessment in the context of predictive, preventive and personalized (3P) medicine.

This book will focus on (i) the methodology of metabolomics, including sample preparation, targeted metabolomics, and untargeted metabolomics based on nuclear magnetic resonance (NMR) or mass spectrometry (MS), and (ii) applications of metabolomics in the research and practice of medical sciences.

Publishing process

Book initiated and editor appointed

Date completed: October 13th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: November 10th 2020

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: January 9th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 30th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 29th 2021

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Xianquan Zhan

Shandong First Medical University

Prof. Xianquan Zhan received his M.D. and Ph.D. training in preventive medicine at West China University of Medical Sciences during 1989-1999. He received his post-doctoral training in oncology and cancer proteomics at Central South University and University of Tennessee Health Science Center (UTHSC). He worked at UTHSC and Cleveland Clinic in USA during 2001-2012, and achieved the rank of Associate Professor at UTHSC. In 2012, he moved to Central South University and Shandong First Medical University as a Professor, and Advisors of MS/PhD graduate students and postdoctoral fellows. He is also the Fellow of Royal Society of Medicine, Fellow of EPMA, European EPMA National Representative, Full member of ASCO, AAAS member, Editor-In-Chief of IJCDT, Associate Editors of EPMA Journal and BMC Genomics, and Guest Editors of Frontiers in Endocrinology and Mass Spectrometry Reviews. He has published 135 articles, 23 book chapters, and 2 US patents in the field of clinical proteomics and biomarkers. He edited 4 academic books: Proteoforms – Concept and Applications in Medical Sciences, Molecular Network Study of Pituitary Adenomas, and Ubiquitin-Proteasome Pathway. As the Guest editor, he edited 11 special issues in SCI journals such as Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Med One. His main research interest focuses on the studies of cancer proteomics and proteoforms, multiomics and biomarkers, and the use of modern omics techniques and systems biology for predictive, preventive and personalized medicine (PPPM) and precision medicine (PM) in cancer.

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Book chapters authored 7

Books edited 1

Introducing your Author Service Manager

Mr. Josip Knapic

As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copy-editing and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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