About the book
Most oncogenes, involved in cellular proliferation, are expressed as proto-oncogenes. If there are chemical, physical, or biological factors that cause mutations in such genes, these genes are mostly upregulated leading to high cellular proliferation and finally cancer. KRAS is an oncogene. It belongs to the Ras family oncogenes. The proteins expressed by Ras family genes are known to play crucial roles in cell division, cell differentiation, and apoptotic cell death. KRAS can be mutated in several pathological conditions including Cardiofaciocutaneous syndrome, Noonan syndrome, Costello syndrome, Autoimmune Lymphoproliferative Syndrome (ALPS), and epidermal nevus. Moreover, its mutations can be observed in different kinds of cancers, including cancers of the pancreas, lung, and colon. Mutated KRAS has an incidence of ∼50% in colorectal cancers. KRAS gene mutations generally indicate a poor prognosis and are associated with resistance to cancer treatment. On the other hand, certain environmental chemicals like organochlorine insecticides, herbicides, N-nitrosamines; polychlorinated biphenyls, and drugs are suggested to lead to mutations in KRAS oncogene.
This book will mainly focus on KRAS oncogene, its mutations, KRAS triggering pathways, MAPK pathway, its association with pathological conditions, cancer and environmental chemicals.