Open access peer-reviewed Edited Volume


Pinar Erkekoglu

Hacettepe University

A pioneering researcher in toxicology, vaccinology, cosmetics, and Board Member of Turkish Pharmacists Association Pharmacy Academia and Board Member of Hacettepe Vaccine Institute. Published more than 150 scientific papers in international/national journals. Associate editor of the Turkish Journal of Pharmaceutical Sciences.


KRAS Gene Oncogene Tumor Suppressor Gene Mutation Cancer Microtubule-Associated Protein (MAP) GTPase Pathological Conditions Epidermal Nevus Noonan Syndrome Costello Syndrome Environmental Chemicals

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About the book

Most oncogenes, involved in cellular proliferation, are expressed as proto-oncogenes. If there are chemical, physical, or biological factors that cause mutations in such genes, these genes are mostly upregulated leading to high cellular proliferation and finally cancer. KRAS is an oncogene. It belongs to the Ras family oncogenes. The proteins expressed by Ras family genes are known to play crucial roles in cell division, cell differentiation, and apoptotic cell death. KRAS can be mutated in several pathological conditions including Cardiofaciocutaneous syndrome, Noonan syndrome, Costello syndrome, Autoimmune Lymphoproliferative Syndrome (ALPS), and epidermal nevus. Moreover, its mutations can be observed in different kinds of cancers, including cancers of the pancreas, lung, and colon. Mutated KRAS has an incidence of ∼50% in colorectal cancers. KRAS gene mutations generally indicate a poor prognosis and are associated with resistance to cancer treatment. On the other hand, certain environmental chemicals like organochlorine insecticides, herbicides, N-nitrosamines; polychlorinated biphenyls, and drugs are suggested to lead to mutations in KRAS oncogene.

This book will mainly focus on KRAS oncogene, its mutations, KRAS triggering pathways, MAPK pathway, its association with pathological conditions, cancer and environmental chemicals.

Publishing process

Book initiated and editor appointed

Date completed: November 17th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: December 15th 2020

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: February 13th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: May 4th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: July 3rd 2021

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About the editor

Pinar Erkekoglu

Hacettepe University

Pınar Erkekoglu graduated from TED Ankara College, Hacettepe University Faculty of Pharmacy (BS) and Anadolu University Public Relations School (BS). She received her PhD degree in 2009. She is working as a professor at Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology and also in Hacettepe University Vaccine Institute Department of Vaccine Technology. She completed a part of her Ph.D. studies on phthalates and oxidative stress in Grenoble, France, in Universite Joseph Fourier and CEA/INAC/LAN after receiving a full scholarship from both the European Union Erasmus Scholarship Program and from Commissariat à l\'énergie atomique et aux énergies alternatives (CEA). She worked as a post-doc and visiting associate at Massachusetts Institute of Technology (MIT) Biological Engineering Department during 2011–2012. She gave lectures as invited speaker in many congresses. She is the Board Member of Hacettepe University Vaccine Institute and also Board Member of Turkish Pharmacists Association Pharmacy Academia. Pınar Erkekoglu has published more than 150 papers in national and international peer-reviewed journals. She is a European Registered Toxicologist (ERT) since 2014. Her main interests are oxidative stress, antioxidants, carcinogenesis mechanisms, reproductive disorders, endocrine diseases, toxic effects of aromatic amines, poisonings, antidote treatments, vaccines and toxic effects of cosmetics and personal care products. She has edited 6 international books and has published 15 book chapters.

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Book chapters authored 4

Books edited 4

Introducing your Author Service Manager

Mrs. Mia Vulovic

As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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