Open access peer-reviewed Edited Volume

Multimodal Optical Bioimaging - Tools, Applications and Image Analysis

Stefan G. Stanciu

Polytechnic University of Bucharest


Julien Colombelli

Institute for Research in Biomedicine


Optical Microscopy Optical Nanoscopy Optical Medical Imaging Correlative Imaging Sample Preparation Protocols Biophotonics Applications Image Segmentation Object Tracking Image Denoising Image Quality Assesment Generative Adversarial Networks Virtual Staining

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About the book

The in-depth understanding of biological species requires a concerted use of various investigation modalities capable of providing valuable and quantitative information on their structure and function. In such efforts, optical techniques play a tremendous role, as they can be ultrafast, non-invasive, and capable of spatial resolutions ranging from macro- to nanoscale. They allow imaging molecules, cells and tissues with high specificity in-vitro, ex-vivo and in-vivo, which is useful not only for fundamental research but also for other important purposes such as diagnostics. Combining complementary optical techniques relying on distinct contrast-mechanisms and operating at different scales represents nowadays the default approach in most experiments aimed at shedding light on still unresolved aspects of key topics such as cell life and fate, or start and progression of pathologies. The potential of such multimodal frameworks can be augmented by means of advanced image analysis tools, which can accelerate research outputs with orders of magnitude and also extract information unavailable to a human expert due to its level of complexity and/or scale. This book intends to provide the reader extensive knowledge on: (i) recent tools with great utility in multimodal optical bioimaging, (ii) advanced protocols for sample preparation methods that enhance bioimaging performance, (iii) important life science applications that exploit the power of complementary optical techniques to resolve aspects difficult or impossible to tackle otherwise, and (iv) latest image analysis methods and workflows capable to extract valuable information from multimodal data sets in a fast and precise way.

Publishing process

Book initiated and editor appointed

Date completed: October 22nd 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: January 11th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 31st 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 30th 2020

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About the editor

Stefan G. Stanciu

Polytechnic University of Bucharest

Stefan G. Stanciu received his Ph.D. in Electronics Engineering and Telecommunications at University Politehnica of Bucharest (UPB) in 2011. He is currently acting as a Senior Scientific Researcher within the Center for Microscopy-Microanalysis and Information Processing of UPB. His main research interests revolve around high- and super-resolution imaging by scanning laser and scanning probe microscopies. Stefan’s current research agenda focuses on the optical characterization of biological species and advanced materials using multimodal imaging approaches, but also on the development of novel machine intelligence methods for automated analysis of microscopy datasets.

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Book chapters authored 2

Books edited 3

Introducing your Author Service Manager

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