Open access peer-reviewed Edited Volume

Central Nervous System Tumors

Feyzi Birol Sarica

Giresun University

Dr.Sarica is currently serving as the Chairman of the Department of Neurosurgery at the Giresun University. He has 23 articles published in Internationally recognized journals, 8 articles published in Nationally published journals, 12 poster papers presented in International Scientific Congresses, 65 poster papers presented in National Scientific Congresses, and 2 chapters published in Proceeding Books.


Symptoms Clinical Presentation Histopathology Molecular Biology Surgery Surgical Treatment Radiosurgery Radiation Therapy Antiangiogenic Therapy Immunotherapy Repeat Surgery Prognostic Factors

Register your interest in contributing to this book

Collaborate with our community and contribute your knowledge.

About the book

Central nervous system (CNS) tumors; represents a heterogeneous group comprising more than 100 tumor types originating from the brain, cerebellum, brain stem, spinal cord, and meninges. Primary CNS tumors constitute 2% of all cancers in adults and 15-25% in children. Among glial tumors, glioblastoma is the most common in adults and pilocytic astrocytoma in childhood. Embryonal tumors are also more common in children and are called medulloblastoma if they are located infratentorial. Other Primary CNS tumors include; Many tumors such as meningioma, pituitary adenoma, hemangioblastoma, craniopharyngioma, germ cell tumors, mixed glio-neuronal tumors can be counted. Secondary CNS tumors; are extraaxially located metastatic tumors and are observed much more frequently than primary CNS tumors. CNS tumors are classified into four grades, from Stage I to IV, according to the Malignant Scale of the World Health Organization (WHO).
The WHO classification in 2007; was based on the histogenesis and cell origin of the tumor. In the latest classification made in 2016; to better characterize the tumor and obtain better data on its prognosis; The combination of molecular and genetic biomarkers and histopathological features of the tumor was used. Despite all current treatment approaches, the median survival time is around 12 months in most GBM patients. Compared with the situation of some types of successfully treated cancers; the survival time of GBM patients is not at an acceptable level today. In the treatment of CNS tumors; surgery, chemotherapy, and radiation treatments (x-rays, gamma rays, electron and proton beams) are used. The therapeutic potential of chemotherapy; New strategies are needed to increase drug concentration at the diseased site, as this largely depends on the ability of the chemotherapeutic agent to achieve effective concentrations at tumor localization. Based on our better understanding of the genetic and molecular characteristics of CNS tumors; Targeted therapies, including vaccines, and treatment protocols such as immunotherapy are promising developments.

This book supposes to be written by many authors who have an internationally honored place in their field to share their ideas about the treatment of CNS tumors. Surgery, Radiotherapy, Chemotherapy and Antiangiogenic Therapy Protocols, Immunotherapy, Molecular Therapy, Specific target-agents therapy with Nanoparticles and Gene Therapy for CNS tumors among the book chapters.
In these sections; there are many practical pieces of information that can help the students who graduated from the Medicine Faculty and specialist doctors who are interested in Neurosurgery.

Publishing process

Book initiated and editor appointed

Date completed: March 25th 2022

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: May 31st 2022

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Register for the book

Approved chapters written in full and submitted

Deadline for full chapters: July 30th 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: October 18th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: December 17th 2022

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Feyzi Birol Sarica

Giresun University

Associate Professor Feyzi Birol SARICA born in 1971 in Germany graduated the Medicine Faculty of Ankara University in 1997 and received the title of Medical Doctor. In 2005, he gaves his expertise thesis named “Prognostic factors in Supratentorial Glial Tumors” at the Neurosurgery Clinic of Ankara Numune Education and Research Hospital and received the title of Neurosurgery Specialist Doctor by Turkish Board Certification. He worked firstly as a Neurosurgery Specialist Doctor and then as an Lecturer in Adana Education and Research Hospital of Medicine Faculty of Baskent University between 2006-2015 years. He worked at the Kudret International Hospital in Ankara in 2016. He started to work as Assistant Professor at Department of Neurosurgery of Medicine Faculty of Giresun University in 2017. He took the title of Associate Professor in March 2018. He is currently serving as the Chairman of the Department of Neurosurgery in Giresun University. He has memberships at Turkish Neurosurgical Society and Nervous System Surgery Association. He has 23 articles published in Internationally recognized journals, 8 articles published in Nationally published journals, 12 poster papers presented in International Scientific Congresses, 65 poster papers presented in National Scientific Congresses and published in Proceeding Books, and 2 International Book Chapter wroten within SCI Index. He participated in Microneurosurgery, Cerebrovascular Surgery, Skull Base Surgery, Gamma Knife Radiosurgery, Hydrocephalus, and Spinal Dysraphism Training. He also participated in many Scientific Congresses, Symposiums and Workshops. He is interested in General Neurosurgery as well as Neurooncology and Cerebrovascular Surgery in recent years.

View profile

Book chapters authored 2

Books edited 0

Introducing your Author Service Manager

Ms. Elena Vracaric

As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

Ask a question

Book will be abstracted and indexed in