Open access peer-reviewed Edited Volume

Endometrial Cancer

Georgios Androutsopoulos

University of Patras


Incidence predisposing factors risk factors Endometrial sampling hysteroscopy Biomarkers DNA ploidy ER/PR receptors p53 proliferation markers Bcl-2 systematic surgical staging lymphadenectomy sentinel lymph node fertility preservation external radiotherapy brachytherapy Chemotherapy molecular targeted therapies

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About the book

Endometrial cancer (EC) is the second most common malignancy of the female reproductive system. The disease usually affects postmenopausal women and the most common presenting symptom is abnormal uterine bleeding. It is widely acceptable that, systematic surgical staging represents the primary EC treatment. Pelvic and para-aortic lymphadenectomy remains an essential part of systematic surgical staging and provides meaningful data regarding the necessity of postoperative adjuvant treatment. However, pelvic and para-aortic lymphadenectomy are associated with significant morbidity. In this light, sentinel lymph node mapping and dissection becomes very popular and epitomizes an equilibrium between systematic lymphadenectomy and no lymphadenectomy in well selected EC patients of low and intermediate risk. Moreover, the dissected sentinel lymph nodes should be evaluated with the ultrastaging approach.
It is interesting to note that, almost 4% of EC patients are below 40 years of age and their management represents a great challenge. Nevertheless, the non-surgical fertility sparing approach could be offered only in well-defined subgroups of young EC patients with early stage disease, strong desire for fertility preservation and detailed counselling.
The clinical role of molecular targeted therapies as an adjuvant treatment in EC patients, remains under investigation. However, there are some promising results regarding their beneficial role in well-defined subgroups of EC patients with specific molecular profile. In conclusion, the early diagnosis as well as the appropriate therapeutic management of EC patients have a direct effect on their quality of life and overall survival. Moreover, the extent of surgical staging as well as the type of postoperative adjuvant treatment should be thoroughly individualized based on EC type, disease stage, fertility issues and patient’s general performance status. The main aim of this book project, is to present most recent advances in diagnosis and treatment of EC.

Publishing process

Book initiated and editor appointed

Date completed: July 11th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

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Approved chapters written in full and submitted

Deadline for full chapters: September 30th 2019

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Full chapters peer reviewed

Review results due: December 19th 2019

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Expected publication date: February 17th 2020

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About the editor

Georgios Androutsopoulos

University of Patras

Georgios Androutsopoulos completed his Degree in Medicine in 1995, at the National and Kapodestrian University of Athens. He received his Medical Specialization in 2006, at the Department of Obstetrics - Gynecology of the University of Patras. He also completed his Doctorate of Medicine “Pregnancy complications in Greek women with inherited thrombophilia” in 2007, at the same Department. He started his clinical career in 1-8-2006, as Obstetrician - Gynecologist at the General, Maternity and Pediatric Hospital of Athens “Mitera” and he served up until 20-1-2009. In 23-1-2009 he became Consultant of Obstetrics and Gynecology at the General Hospital of Amfissas and he served up until 3-1-2012. He started his academic career in 3-1-2012, as Lecturer and Consultant of Obstetrics and Gynecology at the University of Patras and he served up until 20-10-2014. In 20-10-2014, he became Assistant Professor and Consultant of Obstetrics and Gynecology at the same University and holds the position until today. Between 1-11-2016 and 31-10-2017, he was Honorary Clinical Research Fellow in Gynaecological Oncology at Northern Gynaecological Oncology Centre (NGOC), Queen Elizabeth Hospital, Gateshead, United Kingdom. Currently, he is the Head of the Division of Gynecological Oncology of the University of Patras. He has got both academic and clinical experience as well as a heavy workload of research and educational duties. Moreover, he has active participation in Medical Students Educational Program as well as in Residency Training Program at the Department of Obstetrics - Gynecology of the University of Patras. His research interests are mainly focused in Gynecological Oncology. Editor in Scientific Journals: 29. Editorial Board Member in Scientific Journals: 47. Reviewer in Scientific Journals: 99. Participation in Authorship of Scientific Books: 6. Publications in International Scientific Journals with Reviewers: 82. Publications in National Scientific Journals with Reviewers: 11. Citations of Publications: 765. h-index (Scopus): 6, h-index (Scholar): 13, i10-index (Scholar): 25.

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