Open access peer-reviewed Edited Volume

Ketamine Revisited - New Insights into NMDA Inhibitors

Nieves Saiz-Sapena

University of Valencia

Dr. Saiz-Sapena specializes in Anaesthesia and Critical Care at Clinica Universidad de Navarra, Spain, and has over 25 years of professional experience in the areas of neurosurgical anesthesia, anesthesia in the hostile environment, bariatric anesthesia, and difficult airway. She is an active member of several scientific societies including ESA, ASA, SOBA, and SEDAR.


Manuel Granell Gil

Consorcio Hospital General Universitario de Valencia

Dr. Granell Gil has over 28 years of professional experience, especially in thoracic surgery anesthesia, mechanical ventilation, and difficult airway. He is an active member of several scientific societies including ESA, EACTA, and SEDAR, with the role of thoracic anesthesia representative of the EACTA and SEDAR.


Pharmacokinetics Pharmacodynamics Molecular Targets Metabolites NMDA Receptor Glutamatergic Neurotransmission Agents Mechanisms of Action Palliative Care Illicit Use Pediatric Use Veterinary Use Emergency Medicine

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About the book

Ketamine is quite an old drug. It was synthetized in 1962 as a short-acting analogue of phencyclidine, the first clinical trials being published in 1966. It was extensively used in several wars due to its respiratory safety profile, and even included on the World Health Organization's List of Essential Medicines in 1985. Its adverse effects (hallucinogenic and dissociative effects) and the emergence of new hypnotics and analgesics in anesthetic practice restricted its use to veterinary, war scenarios, and pediatrics.

This situation has undergone a profound change in the last 20 years. Molecular and chemical sciences have revealed new data on NMDA receptors, and have allowed the development of different NMDA receptor antagonists that enlarge the scope of ketamine and its compounds.

At this moment, ketamine is increasingly being used in clinical practice. In the operating room, besides its use as an induction or sedative agent, it plays an important role in opioid free anesthesia (OFA), and also as adjuvant together with other drugs or techniques, even regional blocks. Nevertheless, ketamine has jumped beyond this area, to conquer its role in pain medicine (multimodal analgesia, chronic pain, palliative care), critical care (status epilepticus), emergency medicine, and psychiatry (depression).

This book is therefore addressed to a wide range of professionals. It wants to pay tribute to ketamine, this old-new drug, exploring new insights into NMDA receptors and the role of NMDA receptor antagonists in the different actual clinical settings.

Publishing process

Book initiated and editor appointed

Date completed: May 5th 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: June 2nd 2021

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: August 1st 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: October 20th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: December 19th 2021

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About the editor

Nieves Saiz-Sapena

University of Valencia

Nieves Saiz-Sapena is Doctor of Medicine and Surgery from the University of Valencia, and obtained her PhD at University of Navarra, both in Spain. She has over 25 years of professional experience, especially in neurosurgical anesthesia, anesthesia in the hostile environment, bariatric anesthesia, and difficult airway. After a short stay at the Groote Schuur Hospital in Cape Town (South Africa), she specialised in Anaesthesia and Critical Care at Clinica Universidad de Navarra (Spain). She was Associate Professor at the University of Navarra, Head of Department of Anaesthesiology Hospital San Jaime (Torrevieja, Alicante), and Associate Professor Universidad Católica San Vicente Martir, Valencia. Currently she is an active member of several scientific societies including ESA, ASA, SOBA and SEDAR, with a role in Neurociences and in Safety and Quality Sections. She also serves as a reviewer in a number of national and international scientific journals, and combines her job at the General University Hospital in Valencia (Spain) with her participation in professional books, education, and basic and specialist training in Anesthesia and Critical Care.

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Book chapters authored 3

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