Open access peer-reviewed Edited Volume

Ventricular Assist Devices - Advances and Applications in Heart Failure

Enkhsaikhan Purevjav

University of Tennessee Health Science Center

A pioneering researcher in genetics and pathophysiology of pediatric cardiomyopathies appointed Director of the Genetic Cardiology Research Laboratory at the Heart Institute, Le Bonheur Children’s Hospital, and Fellow of American Heart Association (FAHA). Dr. Purevjav earned an MD degree from the Leningrad Pediatric Medical Institute in Russia, and a Ph.D. in Medical Genetics and Molecular biology at Shimane Medical University, Japan.


Hugo Martinez

University of Tennessee Health Science Center

A talented heart transplant cardiologist and multifaceted researcher in pediatric advanced cardiac therapies, cardiovascular genetics, and cardio-oncology, appointed Director of Cardiovascular Genetics Service and Assistant Director for Research, Pediatric Cardiology Fellowship Program at the Le Bonheur Children’s Hospital.

Mohammed Absi

University of Tennessee Health Science Center

Dr. Absi is an Associate Professor of Pediatric Cardiology, certified in Neonatal Advanced Life Support (NALS), Pediatric Advanced Life Support (PALS), and Advanced Cardiac Life Support, he is appointed Medical Director, Pediatric Ventricular Assist Device (VAD) Service at the Le Bonheur Children’s Hospital.

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Jeffrey Towbin

University of Tennessee Health Science Center

Umar Boston

University of Tennessee Health Science Center


Mechanical Circulatory Support (MCS) Ventricular Assist Device (VAD) Preclinical MCS Study Animal Model LVAD Implant Left VAD and Right VAD Congenital Heart Disease (CHD) Risk-Benefit Multidisciplinary Palliative Care Infection Stroke Durable Devices Clinical Trials

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About the book

Heart failure has devastating consequences with a prevalence of over 5.8 million in the USA, and over 23 million worldwide and affecting up to 7.4 per 100,000 children per year. Etiologies of heart failure substantially differ in adult and pediatric patients due to various congenital heart defects, genetic disorders such as syndromic cardiomyopathies, and acquired heart diseases including myocarditis, Kawasaki disease, and endocarditis that are prevalent in pediatric patients. Mechanical circulatory support mainly represented by ventricular assist devices (VADs) has been demonstrated to be efficient in the management of advanced heart failure despite the challenges of unique anatomical and pathophysiological features frequently encountered in adult and pediatric populations. It has been demonstrated that the utilization of VADs in heart failure has currently forward-looking to bridge patients to 1) heart transplant, 2) recovery, or 3) destination therapy. The gap between adult and pediatric VAD therapy is tightening as the result of preclinical translational modeling, clinical research, and advanced technical improvements.

This book will aim to deliver a concise picture of the management and outcomes of advanced heart failure in adult and pediatric patients with emphasis on mechanical circulatory support with VADs. Preclinical animal studies as the experimental platform for demonstrating device safety, reliability, and biocompatibility as well as for elucidating the cellular and molecular responses and underlying mechanisms of reverse remodeling of cardiomyocyte hypertrophy and progressive atrophy to mechanical unloading will also be covered. 

Publishing process

Book initiated and editor appointed

Date completed: March 2nd 2022

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: July 2nd 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: September 20th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: November 19th 2022

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Enkhsaikhan Purevjav

University of Tennessee Health Science Center

Dr. Enkhsaikhan Purevjav earned her MD from the Leningrad Pediatric Medical Institute (LMPI), Russia in 1989, followed by an internship and residency in pediatrics at the Mongolian National Medical University, a fellowship in pediatric cardiology at LPMI, and a Ph.D. in Medical Genetics and Molecular Biology from Shimane Medical University, Japan. Dr. Purevjav joined Baylor College of Medicine and Texas Children’s Hospital as a postdoctoral trainee and instructor and then Cincinnati Children’s Hospital Medical Center as an assistant professor. She currently works as an associate professor at the University of Tennessee Health Science Center where she continues to study the genetics of heart diseases, specifically focusing on pediatric cardiomyopathies and arrhythmias.

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