About the book
Schwann cell is the principal cellular component of the peripheral nervous system (PNS), derived from the neural crest, which retains the multipotential capacities of the neuroepithelial cells in association with many essential properties of glial cells, including the myelin sheath formation of axons in the peripheral nerves. Schwann cells are characterized by high plasticity, which is a crucial factor for nerve regeneration in case of injury of peripheral nerves, providing vital trophic support to the neurons and ensheathing the myelin in demyelinated axons. In case of injury Schwann cells undergo many radical phenotypic changes activating the myelin breakdown initially and up-regulating of cytokines and neurotrophic factors in order to promote the regeneration of the injured axons and the viability of the nerve cells. The main neurological disorders involving Schwann cells are peripheral demyelinating conditions and Schwannomas.
In this book we will aim to describe (a) the procedure of myelination and remyelination in the PNS by Schwann cells, (b) the precursor cells and their role in the homeostatic mechanisms of the PNS, (c) the plasticity of Schwann cells, (d) the response of Schwann cells in nerve injury, (e) the properties of Schwann cells in tissue culture and their interactions with neurons and glia cells and (f) the pathology of Schwann cells in peripheral neuropathies including Guillain-Barre and Charcot-Marie-Tooth disease (CMT).