Open access peer-reviewed Edited Volume

Trinucleotide Repeat Disorders

Martin Henrik Maurer

Heidelberg University


Martin Menzel

Mariaberg Hospital for Child and Adolescent Psychiatry


repeat expansion premutation Huntington?s Disease spinocerebellar ataxias zinc finger proteins CRISPR/Cas9 mental retardation co-morbidity coenzyme Q cysteamine

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About the book

Trinucleotide repeat disorders (TRD), or trinucleotide repeat expansion disorders (TRED), are genetic disorders based on the expansion of a base triplet in coding or non-coding regions of the DNA. Trinucleotide repeat expansions can be compensated to a certain degree, but with larger repeat numbers, subclinical and clinical symptoms and syndroms occur, including Huntington’s disease, Friedreich’s ataxia, spinocerebellar ataxias, and Fragile X syndrom. The present book aims at collecting both clinical and preclinical reports on state-of-the-art procedures in diagnosis, treatment, genetic testing, pharmacological approaches, as well as experimental and ethical issues. 

Publishing process

Book initiated and editor appointed

Date completed: August 12th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: November 1st 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: January 20th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: March 20th 2020

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Martin Henrik Maurer

Heidelberg University

Martin H. Maurer graduated from medical school at the University of Heidelberg, Germany, and McGill University, Montréal, Canada, in 1999 – receiving his MD in 1999. As a post-doctoral fellow in 2003 at the Johns Hopkins University, Baltimore, Md., USA, he concentrated on neurological diseases and was appointed Assistant Professor of Physiology in 2005 and Associate Professor of Physiology in 2007 at the University of Heidelberg. From 2007-08, he was a research group leader in the biotech industry. In 2009-10, he did clinical work in pediatrics, and from 2011 until present in child and adolescent psychiatry. He is now at the Mariaberg Hospital for Child and Adolescent Psychiatry in Gammertingen, Germany, and at a private practice in Stuttgart, Germany. He is Editor-in-Chief of the scientific journal The Application of Clinical Genetics.

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