Open access peer-reviewed Edited Volume

BRCA1 and BRCA2 Mutations

Arli Aditya Parikesit

Indonesia International Institute for Life Sciences, Indonesia


Drug DesignBRCA1/BRCA2 Receptor Structural Bioinformatics Proteomics Biomarkers Protein/DNA Sequencing Breast Cancer Drug Delivery Epidemiology Confounding factors biostatistics

Register your interest in contributing to this book

Collaborate with our community and contribute your knowledge.

Register here

7 days remaining

Submissions close on October 9th 2019

About the book

BRCA1 and BRCA2 genes play an essential role to maintain the integrity of the cellular function to suppress the tumor. However, a simple mutation in the active and binding site of the proteins or the genes will guarantee to shift in functional features, structures, and most possibly creating dysfunctional proteins and genes. In this respect, mutations in proteins and genes that play a role in tumor suppression such as BRCA1 and BRCA2 could be fatal for a human. Thus, it will cause breast cancer. It is the main focus of this book because it is considered as ‘the emperor of all maladies’, and has a very significant mortality rate, especially for women. In this sense, the search for ‘smart drug design’ that adjusts itself to the dynamics of mutation is desirable for targeting the oncoprotein that causes breast cancer. Moreover, as prevention and cautionary measures, mutations data from genomics and proteomics instrument should be extracted to find the possible biomarkers for breast cancer. This book aims to provide clear and concise narration on the diagnosis, prevention, and curation of cancer-based upon the genomics and proteomics-based BRCA1 and BRCA2 mutation data. 

Publishing process

Currently recruiting an editor

Tell us more about your background and your ideas for this book. The most suitable editor will be selected, at which point the publishing process begins.

Become an editor

Chapter proposals submitted and reviewed

Deadline for chapter proposals: TBD

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: TBD

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: TBD

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: TBD

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Arli Aditya Parikesit

Dr. rer. nat Arli Aditya Parikesit is the head of bioinformatics department at i3L. He finished his bachelor and master both in Chemistry, University of Indonesia. In order to pursue the degree in Bioinformatics, he accepted DAAD (German Academic Exchange Service) fellow to conduct doctorate research at Bioinformatics Group, Faculty of Informatics and Mathematics, University of Leipzig, Germany. His doctoral research is focused on the utilization of modern protein domain annotation techniques to the eukaryote domains of life. In addition, Dr. Arli is also an expert on immunoinformatics, in silico drug design, and in silico transcriptomics.

View profile

Book chapters authored 2

Books edited 1

Introducing your Author Service Manager

Mr. Vice Matušan

As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

Ask a question

Book will be abstracted and indexed in