Open access peer-reviewed Edited Volume

BRCA1 and BRCA2 Mutations

Arli Aditya Parikesit

Indonesia International Institute for Life Sciences, Indonesia

Covering

Drug DesignBRCA1/BRCA2 Receptor Structural Bioinformatics Proteomics Biomarkers Protein/DNA Sequencing Breast Cancer Drug Delivery Epidemiology Confounding factors biostatistics

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About the book

BRCA1 and BRCA2 genes play an essential role to maintain the integrity of the cellular function to suppress the tumor. However, a simple mutation in the active and binding site of the proteins or the genes will guarantee to shift in functional features, structures, and most possibly creating dysfunctional proteins and genes. In this respect, mutations in proteins and genes that play a role in tumor suppression such as BRCA1 and BRCA2 could be fatal for a human. Thus, it will cause breast cancer. It is the main focus of this book because it is considered as ‘the emperor of all maladies’, and has a very significant mortality rate, especially for women. In this sense, the search for ‘smart drug design’ that adjusts itself to the dynamics of mutation is desirable for targeting the oncoprotein that causes breast cancer. Moreover, as prevention and cautionary measures, mutations data from genomics and proteomics instrument should be extracted to find the possible biomarkers for breast cancer. This book aims to provide clear and concise narration on the diagnosis, prevention, and curation of cancer-based upon the genomics and proteomics-based BRCA1 and BRCA2 mutation data. 

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About the editor

Arli Aditya Parikesit

Dr. rer. nat Arli Aditya Parikesit is the head of bioinformatics department at i3L. He finished his bachelor and master both in Chemistry, University of Indonesia. In order to pursue the degree in Bioinformatics, he accepted DAAD (German Academic Exchange Service) fellow to conduct doctorate research at Bioinformatics Group, Faculty of Informatics and Mathematics, University of Leipzig, Germany. His doctoral research is focused on the utilization of modern protein domain annotation techniques to the eukaryote domains of life. In addition, Dr. Arli is also an expert on immunoinformatics, in silico drug design, and in silico transcriptomics.

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Book chapters authored 2

Books edited 1

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