Open access peer-reviewed Edited Volume

Trisomy 21 and Other Fetal Aneuploidies

Subrata Dey

West Bengal University of Technology

Covering

Trisomy 21 Aneuploidies Invasive Non-invasive Markers Chronological Ageing Molecular Ageing Maternal Telomere length Non-disjunction Paternal Recombination Proteins Genes Kinetochore Tobacco Contraceptives Environment Life style Congenital heart disease Cancer Neurodegenerative Genes on Chromosome 21 CRISPR Gene editing Mouse model Chromosome 21

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About the book

This book intends to provide a comprehensive source of current information and research developments on Trisomy 21 Down Syndrome and other aneuploidies.To this date well over 100 chromosome aneuploidies have been reported which includes both autosomal and sex chromosomal aneuploidies. Whilst on an individual basis many of these disorders are very rare but together they make a major contribution to human morbidity and mortality. These disorders are account for a large proportion of spontaneous abortion and congenital disability. This book will highlight the recent advances on prenatal screening and diagnosis of aneuploidies, gene editing, diseases associated with Trisomy 21, mechanism of origin of aneuploidies, epidemiology and other exciting areas of research on chromosome aneuploidies. Aneuploidies arise from errors in meiosis, especially in meiosis I. An ongoing challenge for research on aneuploidies is to identify the abnormalities before birth, that is prenatal diagnosis and several markers which include both genetical and biochemical markers are used not only for prenatal screening but also diagnosis. Recent advancement in gene editing mechanism provide us hope for cure of such aneuploidies before birth. This book will highlight the current advancement of research on different types of aneuploidies, management of chromosomal disabilities ,genetic counselling and ethical issues. We hope that the appeal of this book will be of interest to a wider audience.

Publishing process

Book initiated and editor appointed

Date completed: August 29th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: November 18th 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: February 6th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: April 6th 2020

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Subrata Dey

West Bengal University of Technology

Dr. Subrata Dey is the Professor of Biotechnology and Vice Chancellor of the West Bengal University of Technology(Presently named as Maulana Abul Kalam Azad University of Technology). Prof. Dey has long been associated with research on the molecular genetics of Down syndrome and has worked extensively on the etiology of Down syndrome. His current research interests include the identification of genes involved in congenital heart disease, Alzheimer’s disease in both Down syndrome and normal individuals. Dr. Dey has been teaching courses in Genetics, Molecular Biology& Developmental Biology for more than thirty years and has received an award for academic excellence. He is also the founding Director of Centre for Genetic Studies. Prof. Dey is the author of many scientific papers and has edited four books on Down syndrome.

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Book chapters authored 3

Books edited 5

Introducing your Author Service Manager

Ms. Sara Debeuc

As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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