About the book
This book intends to provide a comprehensive source of current information and research developments on Trisomy 21 Down Syndrome and other aneuploidies.To this date well over 100 chromosome aneuploidies have been reported which includes both autosomal and sex chromosomal aneuploidies. Whilst on an individual basis many of these disorders are very rare but together they make a major contribution to human morbidity and mortality. These disorders are account for a large proportion of spontaneous abortion and congenital disability. This book will highlight the recent advances on prenatal screening and diagnosis of aneuploidies, gene editing, diseases associated with Trisomy 21, mechanism of origin of aneuploidies, epidemiology and other exciting areas of research on chromosome aneuploidies. Aneuploidies arise from errors in meiosis, especially in meiosis I. An ongoing challenge for research on aneuploidies is to identify the abnormalities before birth, that is prenatal diagnosis and several markers which include both genetical and biochemical markers are used not only for prenatal screening but also diagnosis. Recent advancement in gene editing mechanism provide us hope for cure of such aneuploidies before birth. This book will highlight the current advancement of research on different types of aneuploidies, management of chromosomal disabilities ,genetic counselling and ethical issues. We hope that the appeal of this book will be of interest to a wider audience.