Open access peer-reviewed Edited Volume

Modifications of Biomolecules

Xianquan Zhan

Shandong First Medical University

Professor Zhan is a pioneering expert in the fields of proteomics, proteoforms, multi-omics, biomarkers, modifications of biomolecules, and 3P medicine in cancer. He is appointed as Fellow of Royal Society of Medicine, Fellow and National Representative of EPMA, and Associate Editor of EPMA Journal and BMC Medical Genomics.


Genome Sequencing RNA Transcriptional Modifications Hydroxymethylation Epigenetics Phosphorylation Glycosylation Ubiquitylation Methylation Myristoylation Proteomics Analysis Cancers Neurodegenerative Diseases

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About the book

The central dogma is a framework to explain the flow of sequence information between information-carrying biomolecules including DNAs, RNAs, and proteins. Modifications are the important molecular events that occur in these biomolecules, which significantly regulate the structures and functions of biomolecules and even the entire biological system. Modifications of biomolecules have been recognized to extensively associate with different pathological and physiological conditions, including cancer, inflammatory disease, neurodegenerative disease, metabolic disease, and diabetics. Modifications of biomolecules are very complex and are the important factors to cause the diversity of biomolecules. There are several modifications such as cytosine methylation and hydroxymethylation occurring in DNAs and at least 20 post-translational modifications occurring in DNA-binding protein histone to regulate the structures and functions of DNAs, at least 150 post-transcriptional modifications such as 3- and 5-methylcytosines (m3C, m5C), N1- and N6-methyladenosines (m1A, m6A, m6Am), pseudouridine (Ψ), 5-hydroxymethylcytosine (hm5C), and 2′-O-methylation (Nm) occurring in RNAs to regulate the structures and functions of RNAs, and 400-600 post-translational modifications such as phosphorylation, glycosylation, ubiquitylation, methylation, sumoylation, acetylation, sulfation, deamidation, nitration, nitrosylation, hydroxylation, succinylation, prenylation, myristoylation, and palmitoylation occurring in proteins to regulate the structures and functions of proteins. Different modifications of biomolecules have different characteristics and methodologies of research. The development of genomics, transcriptomics, proteomics, and bioinformatics is tremendously driving the large-scale studies of biomolecular modifications, including qualitative and quantitative analyses of biomolecular modifications – modified sites and levels at the biomolecules, and further clarify the cellular signaling molecular mechanisms and functions that modifications are involved in. Moreover, there are antagonistic and synergistic effects between biomolecular modifications in a biomolecule to significantly complicate their biological effects. To date, the studies on biomolecular modifications are far insufficient in the fields of life sciences and medical sciences. It is time to strengthen the studies of biomolecular modifications in breadth and depth.

This book will focus on the global identification and quantification of different biomolecular modifications with different omics, and functional roles, and molecular mechanisms of different biomolecular modifications, in different pathological and physiological conditions.

Publishing process

Book initiated and editor appointed

Date completed: November 19th 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: December 17th 2021

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: February 15th 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: May 6th 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: July 5th 2022

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About the editor

Xianquan Zhan

Shandong First Medical University

Xianquan Zhan received his MD and Ph.D. in Preventive Medicine from the West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic during 2001-2012, and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, as well as an advisor to MS/Ph.D. graduate students and postdoctoral fellows. Dr. Zhan is a fellow of the Royal Society of Medicine and the European Association for Predictive, Preventive & Personalized Medicine (EPMA), a national representative for EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is editor in chief of the International Journal of Chronic Diseases & Therapy, associate editor of EPMA Journal and BMC Medical Genomics, and guest editor of Frontiers in Endocrinology, Mass Spectrometry Reviews, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 140 articles, twenty-five book chapters, five books, and two US patents in the field of clinical proteomics and biomarkers.

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Book chapters authored 9

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